鼻咽癌患者的临床结局及其预后研究  

Clinical Outcome and Prognosis of Nasopharyngeal Carcinoma

作　　者：陈光媚[1] 陈奕辉[1] 

机构地区：[1]海南省海口市人民医院耳鼻咽喉科,570208

出　　处：《实用癌症杂志》2014年第2期152-153,159,共3页The Practical Journal of Cancer

摘　　要：目的探讨鼻咽癌患者的临床结局及其预后。方法对100例鼻咽癌患者的生存率进行回顾性分析,并对可能与预后相关的因素进行Cox回归分析。结果 100例患者3年及5年生存率分别为85.4%和67.7%,Ⅰ期、Ⅱ期、Ⅲ期及Ⅳa期3年生存率分别为100.0%、84.2%、71.4%和53.0%,5年生存率分别为90.0%、76.3%、67.9%和40.0%。单因素分析结果显示:T分期、N分期、化疗、颅神经受侵、鼻咽放疗剂量是影响预后的因素(P<0.05);Cox回归分析结果显示:T分期、N分期、颅神经受侵及鼻咽放疗剂量是影响预后的独立风险因素。结论鼻咽癌患者预后较好,T分期、N分期、颅神经受侵及鼻咽放疗剂量是影响预后的独立风险因素。Objective To explore the clinical outcome and prognosis of nasopharyngeal carcinoma .Methods The sur-vival rates of 100 cases of nasopharyngeal carcinoma patients were retrospectively analyzed .The possible factors related with prog-nosis were analyzed by Cox regression analysis .Results 3-and 5-year survival rates of the 100 patients were 85.4% and 67.7%;in stageⅠ,stage Ⅱ,stage Ⅲ and stage Ⅳa patients,the 3-year survival rates were 100.0%,84.2%,71.4% and 53.0%,and the 5-year survival rates were 90.0%,76.3%,67.9% and 40.0%.Univariate analysis showed that T stage ,N stage,chemotherapy,cranial nerves involvement and the nasopharyngeal cavity were prognostic factors (P<0.05);Cox regression analysis showed that T stage ,N stage,cranial nerves involvement and the nasopharyngeal cavity were the independent risk factors affecting prognosis(P<0.05).Conclusion Nasopharyngeal carcinoma patients have good prognosis .T stage,N stage,cranial nerves involved and the nasopharyngeal cavity are the independent risk factors affecting prognosis .

关 键 词：鼻咽癌 临床疗效 预后 影响因素 

分 类 号：R739.63[医药卫生—肿瘤]