体部立体定向放射治疗52例早期非小细胞肺癌的临床观察  

Clinical Observation of Stereotactic Body Radiation Therapy for Early Stage Non-small Cell Lung Cancer

作　　者：张淑莲[1] 马武[1] 景文江[1] 杨晓君[1] 范志刚[1] 王金凤[1] 马军[1] 齐宝华[1] 

机构地区：[1]汉中3201医院肿瘤科,723000

出　　处：《实用癌症杂志》2014年第2期168-170,共3页The Practical Journal of Cancer

摘　　要：目的：探讨体部立体定向放射治疗（ SBRT）早期非小细胞肺癌患者的临床疗效及不良反应。方法52例经病理组织学和（或）细胞学检查证实的早期NSCLC初治患者入组。 SBRT方式：剂量为4．5～6 Gy/次，每天1次，每周5次，共8～12次，总剂量DT48～56 Gy，以50％～70％等剂量线作为处方剂量线包括90％PTV。结果所有患者均完成治疗，随访率100％，治疗3～6个月后，肿瘤完全缓解率80．8％，部分缓解率17．3％，总有效率98．1％。1、2、3年疾病局部控制率分别为100．0％、96．1％、94．2％。1、2、3年总生存率分别为96．0％、92．3％、82．7％。Ⅱ级放射性肺炎发生率为9．6％，无Ⅱ级以上放射性肺炎发生。结论采取SBRT治疗早期NSCLC的1、2、3年肿瘤局部控制率、疾病相关生存率较高，不良反应较少，值得进一步研究推广。Objective To observe the side effects and toxicities of hypofractionated stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer.Methods 52 cases of early stage non-small cell lung cancer patients were treated by SBRT.The 50%-70%dosage curves were selected in the treatment ,2the fractionated doses were 4.5~6 Gy a day,five times a week,totally 8~12 fractions,2the total doses were 48~56 Gy.Results All the patients received the whole treatment , The follow-up rate was 100%.Three to six months after treatment ,2the overall response rate was 98.1%,withCR80.8%,and PR 17.3%.The 1-,2-,and 3-year loal control rates were 100.0%,96.1%,94.2%.The 1-,2-,and 3-year overall survival rates were 96.0%,92.3%,82.7%.The rate of grade 2 radiation pneumonitis was 9.6%and there was no higher grade of radiation pneu-monitis .Conclusion SBRT for early stage non-small cell lung cancer has high 1-,2-,and 3-year tumor control rate ,high surviv-ial rate and less toxicities .It is worth of further study .

关 键 词：癌 非小细胞肺癌 立体定向放射治疗 治疗效果 

分 类 号：R734.2[医药卫生—肿瘤]