局部进展期胃癌根治术后采取同期放化疗的临床效果分析  

Clinical Efficacy of Concurrent Chemoradiotherapy after Radical Gastrectomy for Locally Advanced Gastric Cancer

作　　者：俞倩 陈中安 

机构地区：[1]武汉市商业职工医院消化内科,430021

出　　处：《实用癌症杂志》2014年第3期281-283,共3页The Practical Journal of Cancer

摘　　要：目的探讨局部进展期胃癌根治术后采取同期放化疗的临床效果。方法将59例胃癌患者分为实验组30例和对照组29例。对照组患者于术后采用单纯的化疗方案,实验组则采用术后同期放化疗治疗方案。观察2组术后方案的不良反应发生情况。随访5年,观察2组患者5年内的生存情况及复发情况。结果 2组患者2年内的生存率比较,差异均无统计学意义(P>0.05),但实验组患者3年以上生存率明显高于对照组,差异均有统计学意义(P<0.05)。实验组患者5年内生存率达76.67%,明显高于对照组的44.83%,差异有统计学意义(χ2=6.28,P<0.05)。复发情况实验组明显少于对照组,差异有统计学意义(P<0.05)。2组患者用药后主要的不良反应包括胃肠毒性,肝功能异常,肾功能异常及血液毒性,但2组患者的各项不良反应发生率大致相当,差异均无统计学意义(P>0.05)。结论局部进展期胃癌根治术后采取同期放化疗效果较单纯化疗更有利于提高5年生存率,降低复发率,且不明显增加不良反应,适合临床长期推广应用。Objective To investigate the clinical efficacy of concurrent chemoradiotherapy after radical gastrectomy for locally advanced gastric cancer .Methods 59 cases of gastric cancer patients were divided into the experimental group (n=30) and the control group (n=29).After radical gastrectomy,the control group received chemotherapy alone ,and the experimental group received concurrent chemoradiotherapy .Adverse reactions of the 2 groups were observed.Follow-up was 5 years,survival and recurrence of the 2 groups were observed .Results 2-year survival rates of the 2 groups had no statistical difference ( P>0.05),while the 3-year survival rate of the experimental group was higher than that of the control group ,there had statistical difference (P<0.05).5-year survival rate of the experimental group was 76.67%,which was significantly higher than that of the control group(44.83%),the difference was statistically significant (χ2 =6.28,P<0.05).Recurrence rate of the experimental group was lower than that of the control group ,and the difference was statistically significant (P<0.05),the main adverse reac-tions of the 2 groups were gastrointestinal toxicity ,abnormal liver function ,renal dysfunction and blood toxicity ,but the incidence of adverse reactions of the 2 groups was roughly the same ,the difference was not statistically significant (P>0.05).Conclusion Concurrent chemoradiotherapy after radical gastrectomy for locally advanced gastric cancer was better than chemotherapy alone ,it can improve 5-year survival rate , reduce relapse rate , without significantly increase adverse reactions .It is worthy of long-term clinical application .

关 键 词：局部进展期胃癌 根治术 同期放化疗 化疗 

分 类 号：R735.2[医药卫生—肿瘤]