同期放化疗治疗中晚期食管癌的临床研究  

Clinical Study of Concomitant Radiochemotherapy for Middle and Advanced Esophageal Carcinoma

作　　者：叶金辉[1,2] 赵可雷[1] 胡国林[1] 梁卫江[1] 

机构地区：[1]南方医科大学南方医院,510515 [2]肇庆市第一人民医院,526021

出　　处：《实用癌症杂志》2014年第3期284-286,共3页The Practical Journal of Cancer

摘　　要：目的：观察同期放化疗治疗中晚期食管癌的疗效和不良反应。方法56例中晚期食管癌患者随机分为同期放化疗组和单纯放疗组，同期放化疗组28例放疗同期应用多西他赛（75 mg/m2· d1）＋奈达铂（25 mg/m2· d1-3）化疗，21天为1个周期，共化疗4个周期，放疗期间化疗2个周期，放疗结束后化疗2个周期。单纯放疗组28例，放疗采用直线加速器6MV X线三维适形放疗，总剂量DT60～66 Gy/6～6．5周。结果同期放化组和单纯放疗组近期疗效CR分别为28．57％和21．43％（ P＜0．05）。同期放化组和单纯放疗组1、2、3年生存率分别为87．50％、66．67％、45．83％和62．50％、37．50％、25．00％（P＜0．05），同期放化组生存率均明显高于单纯放疗组（P＜0．05）。但不良反应骨髓抑制、放射性食管炎发生率同期放化组高于单纯放疗组（P＜0．05）。结论同期放化疗治疗中晚期食管癌的疗效较好，且不良反应可耐受，值得临床进一步研究。Objective To study the efficacy and toxicities of concomitant radiochemotherapy for middle and advanced e -sophageal carcinoma .Methods 56 cases of middle and advanced esophageal carcinoma were randomly divided into combined treatment group(n=28) and single radiotherapy group (n=28).The combined treatment group received radiotherapy combined with docetaxel 75 mg/m2 on day 1 and nedaplatin 25 mg/m2 on day 1-3,21 days of chemotherapy was 1 cycle for 4 cycles,with 2 cycles during radiotherapy and 2 cycles after the radiotherapy .The single radiotherapy group were given radiotherapy alone .Both groups received 3-dimensional conformal radiotherapy of 60~66 Gy/6~6.5 weeks.Results The immediate complete response (CR) of the combined treatment group and the single radiotherapy group was 28.57%and 21.43%,respectively(P<0.05).1-, 2-and 3-year survival rates of the combined treatment group and the single radiotherapy group were 87.50%、66.67%、45.83%and 62.50%、37.50%、25.00%,respectively(P<0.05).The combined treatment group had higher survival rates than the single radiotherapy group(P<0.05).However,side effects including bone marrow suppression and radioactive esophagitis were more serious in the combined treatment group (P<0.05).Conclusion Concomitant radiochemotherapy for middle and advanced e-sophageal carcinoma is effective with tolerable toxicities ,and it is worthy of further clinical study .

关 键 词：中晚期食管癌 放化疗 放射治疗 

分 类 号：R735.1[医药卫生—肿瘤]