USP22及其可能靶点在结直肠癌中的表达研究  

USP22 and its potential targets in colorectal adenocarcinoma

作　　者：姜争[1,2] 刘彦龙[3] 王锡山[1,2] 

机构地区：[1]哈尔滨医科大学附属第二医院结直肠肿瘤外科 [2]哈尔滨医科大学大肠癌研究所,150086 [3]哈尔滨医科大学附属第三医院,150081

出　　处：《中华结直肠疾病电子杂志》2014年第1期22-24,共3页Chinese Journal of Colorectal Diseases(Electronic Edition)

基　　金：高等学校博士学科点专项科研基金(20102307110011)

摘　　要：目的探讨USP22及其可能靶点在大肠癌组织中的表达及意义。方法应用RTPCR方法检测82例大肠癌组织中USP22及其可能靶点的mRNA表达情况。结果 USP22 mRNA的表达与BMI-1 mRNA(r=0.790,P<0.0001),c-Myc mRNA(r=0.528,P<0.0001)、cyclin D2 mRNA(r=0.657,P<0.0001),但是与p16INK4a mRNA(r=0.103,P=0.358)和p14ARF mRNA(r=0.039,P=0.731)无关。结论 USP22可能是通过不依赖INK4a/ARF的方式,而通过调节Akt的活性来控制细胞周期的进展。Objective To investigate the expression of USP 22 and its potential targets in colorectal carcinoma.Methods 82 cases of colorectal carcinoma were examined by quantitative RT-PCR.Results Statistical correlation analysis in mRNA level shown that USP 22 was strongly correlated with BMI-1 ( r =0.790,P<0.0001),c-Myc(r =0.528,P <0.0001) and cyclin D2(r =0.657,P <0.0001),but not correlated with p16INK4a(r=0.103,P =0.358)or p14ARF(r =-0.039,P =0.731).Conclusion USP22 may activate BMI1 oncogene-driven pathway signature such as INK4a/ARF or Akt signature via activating the c-Myc-targeted genes such as cyclinD 2,which may act as important role in tumor progression .

关 键 词：USP22 结直肠癌 转移 

分 类 号：R735.34[医药卫生—肿瘤]