Stathmin及Cathepsin B在结直肠癌中的表达  

Expression of Stathmin and Cathepsin B in colorectal cancer

作　　者：杨正多[1] 张丹[1] 吕宏程[1] 张丽[1] 刘光[1] 马卉[1] 王刚[1] 张诗武[1] 

机构地区：[1]南开大学人民医院病理科,天津市300121

出　　处：《中华结直肠疾病电子杂志》2014年第3期18-21,共4页Chinese Journal of Colorectal Diseases(Electronic Edition)

摘　　要：目的研究Stathmin和Cathepsin B在人结直肠癌组织及其转移灶中的差异表达,探讨Stathmin和Cathepsin B在结直肠癌发生发展过程中的作用及其临床病理意义。方法用免疫组织化学染色技术检测158例高分化,中分化及低分化结直肠癌患者手术切除标本及64例相应转移灶组织中Stathmin蛋白和Cathepsin B蛋白的表达情况。结果 Stathmin蛋白及Cathepsin B蛋白在结直肠癌组织及其转移灶中均高表达;高分化结直肠癌样本中Stathmin蛋白及Cathepsin B蛋白在细胞膜或细胞浆阳性表达,而在低分化结直肠癌细胞核,细胞膜及细胞浆中可见二者的阳性表达。结论Stathmin及Cathepsin B可能是判断结直肠癌患者临床病理分级的有用指标。Objective To investigate the differential expression of Stathmin and Cathepsin B in human colorectal cancer tissues and related metastatic foci .And to discuss the clinicopathological significance of these two markers .Methods Immunohistochemical staining for Stathmin and Cathepsin B was performed in the colorectal cancer tissues of 158 cases and 64 related metastatic foci .Results Both Stathmin and Cathepsin B are upregulated in colorectal cancer and related metastatic samples .The location of Stathmin and Cathepsin B transferred from cytoplasm to nuclear in low differentiation colorectal cancer samples compared with high and mediate differentiation samples .Conclusion Stathmin and Cathepsin B might be valuable biomarkers for clinical differentiation of colorectal cancer .

关 键 词：结直肠肿瘤 蛋白 免疫组织化学 

分 类 号：R735.34[医药卫生—肿瘤]