非编码RNA与胰腺癌  

Non-coding RNA and pancreatic cancer

作　　者：陈琳琳[1] 谷欢[1] 彭杰[1] 

机构地区：[1]中南大学湘雅医院消化内科,长沙410008

出　　处：《中南大学学报（医学版）》2014年第5期532-540,卦三,共10页Journal of Central South University ：Medical Science

基　　金：湖南省科技厅科技计划项目(2013SK3028);湖南省教育厅科学研究项目(2011-90);长沙市科技计划项目(K1203051-31)~~

摘　　要：非编码RNA能够调控基因表达、参与表观遗传修饰,细胞分化、增殖、凋亡等多种生命活动。非编码RNA在癌症发生、癌细胞浸润和远端转移等过程中也扮演着重要角色。通过介导基因组超甲基化、转录水平调控、转座序列调控、维持基因组印迹以及DNA损伤修复,调控胰腺癌细胞的生长和凋亡。深入了解非编码RNA在胰腺癌发生发展过程中的分子生物学机制,对非编码RNA在胰腺癌诊断、治疗和预后有重要的理论和应用价值。Non-coding RNA could regulate gene expression, involved in epigenetic modification, and participate in the cell differentiation, proliferation, apoptosis, and other life activities. Noncoding RNA also plays a crucial role in cancer occurrence, cancer cell invasion and distant metastases. h rough mediating genome hyper-methylation, transcriptional regulation, regulation of transposable sequences, maintenance of genomic imprinting and DNA damage repair, noncoding RNA could regulate the growth and apoptosis of pancreatic cancer cells. Understanding the molecular mechanism of non-coding RNA in the development process of pancreatic cancer has important theoretical and practical value in the diagnosis, treatment and prognosis.

关 键 词：非编码RNA 胰腺癌 MIRNA lncRNA 调控 

分 类 号：R735.9[医药卫生—肿瘤]