长沙市体检人群幽门螺杆菌感染与胃黏膜改变及血脂的关系  

Helicobacter pylori infection and gastric mucosa change and blood-lipid in people undergoing the physical examination in Changsha

作　　者：陈志恒[1] 徐灿霞[2] 罗玲[2] 肖静[2] 杨娉婷[1] 刘畅[1] 

机构地区：[1]中南大学湘雅三医院健康管理中心湖南省亚健康诊断与干预工程技术研究中心,长沙410013 [2]中南大学湘雅三医院消化内科,长沙410013

出　　处：《中南大学学报（医学版）》2014年第3期265-269,共5页Journal of Central South University ：Medical Science

基　　金：湖南省科技计划项目(2009TP4026)~~

摘　　要：目的:探讨长沙市体检人群幽门螺杆菌(Helicobacter pylori,H.pylori)感染与胃黏膜改变及血脂的关系。方法:对2 264名体检人群分为H.pylori感染组(n=1 068)与无H.pylori感染组(n=1 196名),H.pylori感染者在进行血糖、血脂等检测的同时进行胃镜检查。结果:H.pylori感染的发生率为47.2%,其胃黏膜糜烂、胃溃疡、十二指肠溃疡、胃黏膜萎缩、胃息肉、血脂异常、三酰甘油升高和高密度脂蛋白胆固醇降低的发生率均高于无H.pylori感染组(P<0.01或P<0.05),H.pylori感染组中有胃黏膜糜烂及溃疡者三酰甘油水平高于胃黏膜无明显异常或轻度胃炎者,而高密度脂蛋白胆固醇低于胃黏膜无明显异常或轻度胃炎者(P<0.05)。结论:H.pylori感染不仅引起胃黏膜损害,同时影响血脂代谢,其可能通过升高三酰甘油和降低高密度脂蛋白胆固醇水平导致冠心病的发生和发展。Objective: To explore the relationship between the Helicobacter pylori(H.pylori) infection and gastric mucosa change and blood-lipid in pelople undergoing the physical examination in Changsha. Methods: A total of 2 264 pelople undergoing physical examination were divided into an H. pyloripositive group(n=1 068) and an H. pylori-negative group(n=1 196). Gastric mucosa change was diagnosed by gastroscopy, blood-lipid and blood sugar were detected, and the statistical analysis was performed. Results: h e incidience rate of H.pylori infection was 47.2%. h e incidence rate of gastric mucosalerosion, gastric ulcer, duodenal ulcer, gastric mucosal atrophy, gastric polyp, dyslipidemia, increase of triglyceridewere(TG) and decrease of the high density lipoprotein cholesterol(HDL-C) in the H.pylori-positive group were all higher than those in the H.pylori-negative group(P<0.01 or P<0.05). In the H. pylori-positive group, the level of TG in people with gastric mucosal erosion, gastric ulcer and duodenal ulcer was higher than that in people with normal gastric mucosa or mild gastritis, and HDL-C was lower than that in people with normal gastric mucosa or mild gastritis. Conclusion: H. pylori infection can induce the gastric mucosa injury and dyslipidemia, which may result in the occurrence and development of coronary heart disease by increasing TG and decreasing HDL-C, thus increasing the risk of atherosclerosis.

关 键 词：幽门螺杆菌 感染 流行病学 胃镜检查 血脂 

分 类 号：R57[医药卫生—消化系统] R541.4[医药卫生—内科学]