错配修复基因和结肠癌的关系  

Relation between mismatch repair genes and colon cancer

作　　者：马俊丽[1] 曾珊[1] 

机构地区：[1]中南大学湘雅医院肿瘤科,长沙410008

出　　处：《中南大学学报（医学版）》2014年第2期190-194,共5页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(30770971;30800518;81102046;81070362;81172470);湖南省自然科学基金(11JJ2049;12JJ3118)~~

摘　　要：错配修复系统(mismatch repair,MMR)是机体DNA修复机制的一种形式,主要纠正碱基错配,防止基因突变和维持基因组稳定性。miRNA介导的MMR表达异常和结肠癌的发生发展关系密切,MMR表达缺陷(dMMR)的结肠癌有独特的临床特征,可以作为结肠癌的潜在预后及疗效预测因子。研究MMR与结肠癌的发生、MMR与miRNA的相互关系及MMR疗效预测等具有非常重要的意义。Mismatch repair(MMR) system is one form of DNA repair mechanisms, which plays an important role in rectifying the mismatch of base pairs, reducing gene mutations and keeping genome stability. Abnormal expression of MMR regulated by miRNA is closely related to the development of colon cancer. Functional defects of MMR(dMMR) with particular clinical characteristics can be used as a potential prognostic and predictive biomarker. h is article reviews the relation between MMR system, miRNA and colon cancer.

关 键 词：错配修复基因 微卫星不稳定性 MIRNA 结肠癌 

分 类 号：R735.35[医药卫生—肿瘤]