新疆地区散发性结直肠癌患者hMSH2表达的预后意义  

hMSH2 aberrant expression in patients with sporadic colorectal cancer in Xinjiang

作　　者：王海燕[1] 孙振强[2,3] 叶立功 徐佩[1] 赵云霞[1] 唐丽娜[1] 顿晓熠[1] 

机构地区：[1]中国人民解放军第474医院血液内分泌消化科,乌鲁木齐830011 [2]中南大学肿瘤研究所,长沙410078 [3]新疆医科大学附属肿瘤医院胃肠外科,乌鲁木齐830011

出　　处：《中南大学学报（医学版）》2014年第6期552-557,共6页Journal of Central South University ：Medical Science

基　　金："十一五"科技支撑计划项目(2006BAI02A06);新疆医科大学科研创新基金(XJC201267)~~

摘　　要：目的:探讨新疆地区散发性结直肠癌患者hMSH2表达的预后意义。方法:收集新疆地区行结直肠癌手术的327例患者临床病理资料,采用免疫组织化学PV-9000二步法检测hMSH2蛋白表达水平,比较表达正常组与缺失组在生存方面的差异。结果:10.7%的患者存在hMSH2表达的缺失。生存分析的结果显示hMSH2表达缺失组较正常组生存时间更长,差异具有统计学意义(P<0.05)。结论:hMSH2表达可作为新疆地区散发性结直肠癌患者的一个独立的预后因素。Objective: To explore the significance of hMSH2 aberrant expression in patients with sporadic colorectal cancer in Xinjiang Uygur Autonomous Region.Methods: Clinicopathological parameters and postoperative samples of 327 patients with sporadic colorectal cancer were collected in Xinjiang Uygur Autonomous Region. Immunohistochemistry PV-9000 two-step method was performed to measure hMSH2 expression in the postoperative pathologic specimens. Prognostic value of hMSH2 expression was evaluated. Results: Thirty-five(10.7%) patients showed aberrant nuclear staining of hMSH2 expression. The patients with aberrant expression of hMSH2 showed better prognosis than the normal expression group, with significant difference(P<0.05). Conclusion: In Xinjiang, aberrant hMSH2 expression can be regarded as an independent prognostic factor in patients with sporadic colorectal cancer.

关 键 词：错配修复基因 结直肠癌 HMSH2 预后 

分 类 号：R735.34[医药卫生—肿瘤]