软骨肉瘤的相关分子机制研究进展  

Advances in Research on Related Molecular Mechanisms of Chondrosarcoma

作　　者：冯和林[1] 赵亚恒[1] 郑丽华[2] 冯建刚[1] 

机构地区：[1]河北医科大学第四医院骨科,石家庄050011 [2]河北医科大学第四医院乳腺外科,石家庄050011

出　　处：《肿瘤防治研究》2014年第4期416-420,共5页Cancer Research on Prevention and Treatment

基　　金：河北省科技厅支撑课题基金资助项目(11276156)

摘　　要：软骨肉瘤是骨组织第二大常见恶性肿瘤,约占恶性骨肿瘤的20%,它具有局部侵袭性和远处转移性。各种肿瘤抑癌基因、致癌基因、细胞因子和错综复杂的信号级联放大途径都和软骨肉瘤的发病相关,并且同源染色体丢失、核型改变也关系到软骨恶变。CCN6、WISP-1、HMGB-1、TNF-α、IL-6、IGF和COXs的异常表达能够通过激活一系列的信号转导途径及分子来促进软骨肉瘤细胞的转移。近年众多研究表明上述因素和软骨肉瘤的发病机制有关。本文将对这些因素在软骨肉瘤的发生发展方面的作用作一简要综述。Chondrosarcoma is the second most common malignant bone tumor with a potent capacity to invade locally and cause distant metastasis and accounts for approximately 20% of malignant bone lesions. Various tumor suppressor genes, oncogenes, cytokines, and intricate networks of signaling cascades have been associated with chondrosarcoma. The malignant cartilage-producing is associate with the loss of chromosomes or karyotypic alterations. The abnormal expression of CCN6, WISP-1, HMGB-1, TNF-α, IL-6, IGF and COXs have increased the migration of human chondrosarcoma cells by activating a series of signal transduction pathways and molecules. In recent years, accumulating studies have suggested their association with the pathogenesis of chondrosarcoma. This article reviews the role of these factors in the genesis and development of human chondrosarcoma.

关 键 词：骨肿瘤 软骨肉瘤 CCN 高迁移率族蛋白-1 肿瘤坏死因子-α 环氧合酶 

分 类 号：R738.3[医药卫生—肿瘤]