恶性胸腔积液中CD4+T细胞的研究进展  

Review on CD4+T Cells in Malignant Pleural Effusion

作　　者：宫原[1] 陈世雄[1] 

机构地区：[1]三峡大学第一临床医学院宜昌市中心人民医院呼吸内科,湖北宜昌443003

出　　处：《肿瘤防治研究》2014年第5期501-504,共4页Cancer Research on Prevention and Treatment

基　　金：湖北省科技计划资助项目(2012FFB06301);湖北省自然科学基金资助项目(2011CDB178);湖北省教育厅自然科学研究项目计划资助课题(Q20111202)

摘　　要：细胞免疫是人体免疫系统的重要组成部分,主要由CD8+细胞毒T细胞及CD4+辅助性T细胞介导机体免疫反应,其中CD4+T细胞又包括多个亚群,如Th1、Th2细胞,目前又发现了新的亚群如Treg、Th17、Th9,均不同程度参与了疾病的免疫过程,而对于肿瘤的抑制或促进作用机制尚不清楚。本综述收集了恶性胸腔积液中有关CD4+T亚群变化及可能机制的最新资料,分析其在肿瘤中的特性和作用以了解在肿瘤局部微环境的效应机制,为肿瘤的诊断治疗提供新的靶点。Cellular immunity is an important part of human immune system, mainly mediated by CD8+ cytotoxic T cells and CD4+ helper T cells. CD4+T cells include many subsets, for example, Th1 and Th2 cells, and the newly discovered subsets include Treg, Th17 and Th9 cells which are all involved in the tumor immune reaction at different degrees. But the mechanisms of inhibiting or promoting tumors remain unclear. This review collected the latest information of CD4+T subsets in malignant pleural effusion, including their changes, the possible mechanism, their roles in the tumor immune reaction, and provided a new targets for diagnosis and treatment of tumor.

关 键 词：调节性T细胞 辅助性Th17细胞 辅助性Th9细胞 胸腔积液 

分 类 号：R730.5[医药卫生—肿瘤]