RNA干扰技术抑制涎腺腺样囊性癌的研究进展  

Research Progress of RNA Interference Inhibiting Salivary Adenoid Cystic Carcinoma

作　　者：李战[1] 农晓琳[1] 

机构地区：[1]广西医科大学口腔医学院口腔颌面外科,南宁530021

出　　处：《肿瘤防治研究》2014年第6期689-692,共4页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金资助项目(30060082;8 1 3 6 0 4 0 4);教育部"春晖计划"科研启动基金(教外司留[2003]593-7);广西自然科学基金重点项目(2010GXNSFD013047);广西科学基金资助项目(桂科回0836013);广西卫生厅重点科研项目(重200006;重200927);广西教育厅立项项目(2006-64)

摘　　要：涎腺腺样囊性癌是头颈部常见的恶性肿瘤之一,具有早期易血行转移,嗜神经侵袭,术后易局部复发及远处转移等特点。目前,对丧失手术机会的患者尚缺乏有效的治疗手段。RNA干扰作为一种可高效、特异性沉默目的基因的手段已被广泛应用于各种肿瘤研究。通过利用RNA干扰技术沉默腺样囊性癌的癌基因、抗凋亡因子及黏附、迁移相关因子等基因的表达后,腺样囊性癌的发展受到了明显的抑制。本文拟对涎腺腺样囊性癌的RNA干扰治疗进展进行综述。Salivary adenoid cystic carcinoma(SACC) is one of the common types of malignancies in head neck region.With high aggressive potential,SACC tends to invade blood vessels and nerves at an early stage and is prone to recurrence and distant metastasis.Yet, there are no effective therapies for patients in the late stages which have no indication for operation.RNA interference(RNAi) is a gene-silencing technology, resulting in the sequence-specific silence of target gene efficiently and specifically. It has been applied widely in the research of various tumors. RNAi technology has been successfully used to inhibit SACC by suppressing the expression of oncogenes, anti-apoptotic factors and factors associated with adhesion and metastasis. This review describes current research progress of RNA interference inhibiting salivary adenoid cystic carcinoma.

关 键 词：腺样囊性癌 RNAI 基因沉默 治疗 

分 类 号：R73[医药卫生—肿瘤]