皮纹(单、双眼皮)与食管癌患病风险关系的病例对照研究  

A Case Control Study on Relationship between Dermatoglyph(Single and Double Eyelids) and Risk of Esophageal Cancer

作　　者：崔娟[1,2] 范宗民[1] 侯志超[1] 户彦龙[1] 申芳芳[1,2] 周胜理[1] 李江曼[1,3] 崔纪丽[1] 赵学科 胡守佳[4] 王立东[1] 

机构地区：[1]河南省食管癌重点开放实验室郑州大学第一附属医院,郑州450052 [2]新乡医学院第三附属医院肿瘤转化医学重点实验室 [3]河南科技大学第一附属医院检验科 [4]三全医学院

出　　处：《肿瘤防治研究》2014年第3期199-202,共4页Cancer Research on Prevention and Treatment

基　　金：国家科技部863重大项目资助(2012AA02A209;2012AA02A201)

摘　　要：目的探讨单、双眼皮与食管癌患病高风险的关系。方法采用问卷调查、家访(80%以上)和非条件Logistic回归分析方法,对2 262例病例组(经组织病理学确诊为食管鳞状细胞癌患者)及3 459例对照组(均经食管内镜检查确诊为非癌人群)单、双眼皮和其他临床资料等进行相关性分析。结果病例组单、双眼皮频率(58%vs.42%)高于对照组(51%vs.49%)(P【0.001),单眼皮人群患食管癌的风险性比双眼皮人群高(OR=1.29,95%CI:1.15-1.44,P【0.001)。年龄分层分析发现:45~64岁的单眼皮人群发生食管癌的风险高于同年龄段双眼皮人群(OR:1.26-1.61,95%CI:1.08-2.02)。结论单眼皮表型与食管癌患病高风险相关,提示单眼皮可作为食管癌高风险评估的危险指标之一,并为进一步研究皮纹与食管癌发生的相关分子机制,提供了线索。Objective To investigate the relationship between single and double eyelids and esophageal cancer risk.Methods The prevalences of single and double eyelids and esophageal cancer, were recorded by questionnaires, interview(over 80% at home) in 2 262 case with esophageal squamous cell carcinoma and 3 459 controls and unconditional Logistic regression analysis was performed on clinicopathology.Results The prevalence of single and double eyelids in cases was higher than that in controls(P<0.001). Population with single eyelid had higher risk of esophageal cancer than those with double eyelids(OR=1.29,95%CI:1.15-1.44, P <0.001). Stratifi ed analysis by age, the subjects aged from 45 to 64 years with single eyelid had higher risk of esophageal cancer than those with double eyelids(OR:1.26-1.61,95%CI:1.08-2.02).Conclusion Single eyelid could be used as an indicator to indicate the high susceptibility of esophageal cancer and further provides clues to research links between dermatoglyph and molecular mechanism of esophageal cancer.

关 键 词：食管癌 单双眼皮 高风险指标 

分 类 号：R735.1[医药卫生—肿瘤]