上皮间叶转化相关蛋白在三阴性乳腺癌组织中的联合表达及其与预后的关系  

Combined Expressions of Epithelial-Mesenchymal Transition Related Proteins in Triple-Negative Breast Cancer and Its Prognostic Signifi cance

作　　者：漆楚波[1] 龚益平[2] 王明伟[1] 徐唐鹏[3] 陈琼荣[1] 夏和顺[1] 

机构地区：[1]湖北省肿瘤医院病理科,武汉430079 [2]湖北省肿瘤医院乳腺科,武汉430079 [3]武汉大学中南医院肿瘤科

出　　处：《肿瘤防治研究》2014年第3期265-268,共4页Cancer Research on Prevention and Treatment

基　　金：湖北省自然科学基金资助项目(2009CDB333);武汉市科学技术计划资助项目(201271130453)

摘　　要：目的检测上皮间叶转化相关蛋白E-cadherin、β-catenin和Vimentin在三阴性乳腺癌中的联合表达及其与预后的关系。方法免疫组织化学分别检测E-cadherin、β-catenin和Vimentin在51例三阴性乳腺癌中的表达,分析其联合表达与预后的相关性。结果 E-cadherin或β-catenin表达的缺失或Vimentin表达的增高均为异常表达。3项均正常、1~2项不正常以及3项均不正常的病例数分别为1例(1.96%)、37例(72.55%)、13例(25.49%)。3项均不正常组的5年内无瘤生存较其他组明显缩短(Log rank检验,P【0.01)。结论上皮间叶转化相关蛋白E-cadherin、β-catenin和Vimentin的联合检测有助于区分三阴性乳腺癌的异质性。Objective To investigate the relationship between expressions of epithelial-mesenchymal transition related proteins(E-cadherin, β-catenin and Vimentin) and prognosis in triple-negative breast cancer. Methods The expressions of E-cadherin, β-catenin as well as Vimentin were examined by immunohistochemistry in 51 patients with breast cancer. The relation between combined expression of 3 markers and prognostic signifi cance was analyzed. Results The loss of E-cadherin or β-catenin expression and over-expression of Vimentin were defined as abnormal expression. The cases with 3 markers normal expressions, 1-2 markers normal expressions, and 3 markers abnormal expressions were 1(1.96%), 37(72.55%) and 13(25.49%), respectively.Patients with abnormal expression of 3 markers had shorter disease free survival(DFS),compared with those without. Conclusion The combined expression of E-cadherin,β-catenin as well as Vimentin were useful in discriminating the heterogeneity of triple-negative breast cancer.

关 键 词：乳腺肿瘤 预后 上皮间叶转化 钙黏蛋白 

分 类 号：R737.9[医药卫生—肿瘤]