骨肉瘤发病机制的研究进展  

Progress on Osteosarcoma Pathogenesis

作　　者：赵亚恒[1] 冯和林[2] 郑丽华[1] 贾志峰[2] 冯建刚[2] 

机构地区：[1]河北医科大学研究生学院,石家庄050011 [2]河北医科大学第四医院骨科

出　　处：《肿瘤防治研究》2014年第3期283-286,共4页Cancer Research on Prevention and Treatment

基　　金：河北省科技厅支撑课题(11276156)

摘　　要：骨肉瘤(osteosarcoma,OS)是骨组织中最常见的恶性肿瘤,每年全世界的发病率为4/105。其恶性程度高,易发生于生长较快的青年人,男性发病率高于女性,严重威胁着患者身心健康。但其发病机制尚不清楚,现就影响其发病的因素:同源染色体6p21、8q24、12q14扩增以及10q21.1杂合子丢失、p53和Rb抑癌基因异常、转录调节因子活化蛋白-1(AP-1)、原癌基因、转化生长因子(TGF)、胰岛素样生长因子(IGF)和结缔组织生长因子(CTGF)失调、WWOX、miRNAs、14q32 miRNAs-cMYC相互作用、miRNA-29a沉默等做简要概括。这些因素会对预防及治疗骨肉瘤带来新的方向。Osteosarcoma(OS) is the most common bone cancer with high degree of malignancy. The worldwide disease incidence is 4/105 per year. OS is prone to young people who grow faster. Males have a higher incidence than females. But OS pathogenesis has not been clear to date. Now, we are going to make a brief review on the risk factors, such as amplifi cation of homologous chromosomes 6p21, 8q24 and 12q14, 10q21.1 heterozygote lost, abnormal expressions of tumor suppressor genes p53 and Rb, disorders of transcription factor activator protein-1(AP-1), protooncogene, transforming growth factor(TGF), insulinlike growth factor(IGF) and connective tissue growth factor(CTGF), interaction of WWOX, miRNAs, and 14q32 miRNAs-cMYC, silence of miRNA-29a, etc.. These factors will open a novel avenue in the prevention and treatment of osteosarcoma.

关 键 词：骨肉瘤 发病机制 WWOX MIRNAS 

分 类 号：R738.1[医药卫生—肿瘤]