鼻咽癌中E-cadherin和N-cadherin的表达及临床意义  

Expression and Clinical Significance of E-cadherin and N-cadherin in Nasopharyngeal Carcinoma

作　　者：陈曦[1] 彭纲[2] 李跃华[2] 王涛[2] 

机构地区：[1]湖北省黄石市第一人民医院肿瘤内一科,湖北黄石435000 [2]华中科技大学同济医学院附属协和医院肿瘤中心

出　　处：《肿瘤防治研究》2014年第1期27-30,共4页Cancer Research on Prevention and Treatment

摘　　要：目的探讨E-钙黏蛋白(E-cadherin)和N-钙黏蛋白(N-cadherin)在鼻咽癌组织中的表达水平及其与临床病理特征的关系。方法应用免疫组织化学SABC法检测72例鼻咽癌和12例慢性鼻咽炎性组织中E-cadherin、N-cadherin的表达情况,并结合临床病理特征进行相关性分析。结果E-cadherin在慢性鼻咽炎性组织中阳性表达率高于鼻咽癌组织,而N-cadherin在慢性鼻咽炎性组织中阳性表达率低于鼻咽癌组织。两者的表达与性别、年龄及远处转移无明显相关;而与T分期、N分期及临床分期密切相关;E-cadherin与N-cadherin两者之间表达呈明显负相关。结论在鼻咽癌组织中E-cadherin的低表达和N-cadherin异常表达与肿瘤的局部浸润和淋巴结转移有关。Objective To investigate the expressions of E-cadherin and N-cadherin in nasopharyngeal tissues and their relationship with pathological features. Methods The expressions of E-cadherin and N-cadherin in 72 NPC samples and 12 samples in patients with chronic nasopharyngitis were detected by immunohistochemical SABC. The relationship between the expressions and pathological features was also analyzed.Results In chronic nasopharyngitis samples, the positive expression of E-cadherin was significantly higher, while that of N-cadherin was significantly lower, than that in NPC samples respectively. The positive expression of E-cadherin and N-cadherin had no significant correlation with gender, age and distal metastasis, but had close relationship with T, N and clinical stage. Besides, E-cadherin expression was negatively correlated with N-cadherin expression. Conclusion Low expression of N-cadherin and aberrant expression of E-cadherin are related with local tumor invasion and lymphatic metastasis.

关 键 词：鼻咽癌 E-钙黏蛋白 N-钙黏蛋白 上皮-间质转化 

分 类 号：R739.63[医药卫生—肿瘤]