恶性黑色素瘤内科治疗研究进展  

Progression of Medical Treatment for Malignant Melanoma

作　　者：张艳丽[1] 祝顺琴[2] 刘亚玲[1] 崔红娟[2] 

机构地区：[1]河北医科大学第三附属医院皮肤科,石家庄050000 [2]西南大学家蚕基因组生物学国家重点实验室

出　　处：《肿瘤防治研究》2014年第1期74-78,共5页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金资助项目(31271462)

摘　　要：恶性黑色素瘤是一种恶性程度高、易转移、预后差、对放化疗均不敏感的恶性肿瘤。近年来,我国恶性黑色素瘤发病率迅速增长。多数早期患者通过手术能够得到治愈,但对于中晚期患者,标准化疗效果欠佳,因此探索高效低毒的治疗方法尤为重要。近几年黑色素瘤在临床治疗方面有所突破,本文结合近年来有关文献对其研究进展进行综述。Malignant melanoma is an aggressive cancer with a propensity for distant metastasis and often fails to respond to chemotherapy and radiation therapy, resulting in poor prognosis. In recent years, the incidence rate of malignant melanoma increases rapidly in China. The majority of patients with early-stage melanoma can be cured by surgical excision, while for the advanced tumor, the standard chemotherapeutic approaches used in the treatment have been disappointing. The challenge for the oncologist in future will be to identify new chemotherapeutic regimens with high efficacy and low toxicity. Various therapeutic approaches have been studied and exciting advances have been made for the treatment of melanoma, this review summarized the treatments of malignant melanoma with a focus on literatures of recent years.

关 键 词：恶性黑色素瘤 免疫治疗 靶向免疫治疗 化学治疗 

分 类 号：R739.5[医药卫生—肿瘤]