自发性细菌性腹膜炎患者腹水LPS、IL-6、PCT测定的临床意义  

The clinical significance of measurement of LPS,IL - 6,PCT in ascites of spontaneous bacterial peritonitis

作　　者：陈士华 周海鸥[2] 花扣珍[2] 蒋锦琴[2] 

机构地区：[1]平湖第一人民医院,浙江平湖314200 [2]浙江医学高等专科学校,浙江杭州310053

出　　处：《浙江医学教育》2009年第1期46-48,共3页Zhejiang Medical Education

摘　　要：目的:探讨肝炎肝硬化并发自发性细菌性腹膜炎(SBP)患者腹水中内毒素(LPS)、白细胞介素-6(IL-6)、降钙素原(PCT)水平的变化及其临床意义。方法:183例肝炎肝硬化并发腹水患者作腹水LPS、IL-6和PCT水平检测,所有SBP患者腹水均作细菌培养。结果:97例SBP患者腹水LPS、IL-6、PCT水平明显高于86例无SBP患者(P<0.01),G-菌SBP腹水中的1PS水平明显高于G^+菌SBP腹水(P<0.01)。结论:腹水LPS、IL-6、PCT水平的检测有助于SBP的诊断,并且腹水LPS水平的检测还有助于SBP病原菌的鉴别。[Objective]To investigate the changes of endotoxin(LPS),Interleukin- 6(IL - 6),procalcitonin(PCT) levels in ascites and their clinical significance in patients with spontaneous bacterial peritonitis(SPB).[Method]LPS、IL - 6 and PCT levels in183 patients with cirrhotic ascites were determined.All SBP patients' ascites did bacterial culture.[Result]LPS、IL- 6 and PCT levels in 97 patients with SBP were significantly higher than the other 86 patients without SBP(P < 0.01).The levels of LPS in ascites with G- bacteria were significantly higher than those with G+ bacteria(P < 0.01).[Conclusion] Measurement of LPS、IL - 6 and PCT in ascites is helpful for physician to diagnose SBP and the levels of LPS is helpful in distinguishing SBP pathogenic bacteria.

关 键 词：肝硬化 自发性细菌性腹膜炎 内毒素 白细胞介素-6 降钙素原 

分 类 号：R575.2[医药卫生—消化系统]