Highly efficient heterogeneous procedure for the conjugate addition of amines to electron deficient alkenes  

作　　者：XueZheng Liang  NanNan Quan  Jian Wang JianGuo Yang 

机构地区：[1] Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University, Shanghai, 200062, China [2] Energy Institute, Department of Materials Science and Engineering, Pennsylvania State University, University Park, PA 16802, USA

出　　处：《Science China Chemistry》2009年第7期874-878,共5页中国科学（化学英文版）

基　　金：Supported by the National Key Project of Scientific and Technical Supporting Programs Funded by Ministry of Science and Technology of China (Grant No. 2006BAE03B06);Shanghai Leading Academic Discipline Project (Grant No. B409);Shanghai International Cooperation of Science and Technology Project (Grant No. 06SR07101)

摘　　要：The novel efficient procedure has been developed for the conjugate addition of amines to electron deficient alkenes. K<SUB>2</SUB>CO<SUB>3</SUB> supported on different carriers have been synthesized for the conjugate addition of amines and alkenes. After optimizing the reaction conditions, K<SUB>2</SUB>CO<SUB>3</SUB>/MgO was chosen as the most efficient catalyst for the reactions. The results showed that the catalyst was very efficient for the conjugate addition of amines to electron deficient alkenes with the excellent yields in several minutes. Operational simplicity, without need of any solvent, low cost of the catalyst used, high yields, reusability, excellent chemoselectivity, and applicability to large-scale reactions are the key features of this methodology.The novel efficient procedure has been developed for the conjugate addition of amines to electron deficient alkenes. K2CO3 supported on different carriers have been synthesized for the conjugate addition of amines and alkenes. After optimizing the reaction conditions, K2CO3/MgO was chosen as the most efficient catalyst for the reactions. The results showed that the catalyst was very efficient for the conjugate addition of amines to electron deficient alkenes with the excellent yields in several minutes. Operational simplicity, without need of any solvent, low cost of the catalyst used, high yields, reusability, excellent chemoselectivity, and applicability to large-scale reactions are the key features of this methodology.

关 键 词：heterogeneity CONJUGATE addition CHEMOSELECTIVITY catalysis SOLVENT-FREE 

分 类 号：O621.2[理学—有机化学]