原发性肝癌患者肝动脉化疗栓塞术前后血清TNFα和TGFβ_1浓度变化及意义探讨  

Observation of TNFα and TGFβ_1 changes in serum of patients with primary hepatic cancer before and after transcatheter arterial chemoembolization and its clinical significance

作　　者：陆忠华[1] 邓俊[1] 杨小娟[1] 裴豪[1] 庄琳旎[1] 陈卫[1] 

机构地区：[1]无锡市传染病医院,无锡214005

出　　处：《中国肝脏病杂志（电子版）》2009年第2期14-16,共3页Chinese Journal of Liver Diseases：Electronic Version

摘　　要：目的观察原发性肝癌患者肝动脉化疗栓塞术(TACE)前后血清肿瘤坏死因子α(TNFα)、转化生长因子β1(TGFβ1)的浓度变化。方法随机选择30例确诊的原发性肝癌患者,用酶联免疫吸附试验法检测患者术前和术后两周血清肿瘤坏死因子α(TNFα)、转化生长因子β1(TGFβ1)的浓度变化。结果治疗后两周患者肿瘤坏死因子α(TNFα)、转化生长因子β1(TGFβ1)的浓度变化明显下降,与治疗前比较,差异有显著统计学意义(P<0.01)。结论血清肿瘤坏死因子、转化生长因子的浓度对TACE治疗原发性肝癌的预后观察具有一定的临床实用价值。Objective To observe the density changes of tumor necrosis factor α(TNF α) and transformation growth factor β1(TGF β1) in serum of patients with primary hepatic cancer before and after the treatment of transcatheter hepatic arterial chemoembolization(TACE).Methods Thirty cases indentified as primary hepatic cancer were randomly selected and the density changes of TNF α and TGF β1 by enzyme linked immunosorbent assay(ELISA) before and after two weeks' treatment were detected.Results The density change of patients' TNF α and TGF β1 dropped off obviously after two weeks' treatment.Compared with the pretreatment,the difference was significantly statistical(P < 0.01).Conclusions The density of TNF α and TGF β1 had certain clinical practical value to primary hepatic cancer's prognosis observation treated by TACE.

关 键 词：原发性肝癌 肝动脉化疗栓塞 肿瘤坏死因子α 转化生长因子Β1 

分 类 号：R735.7[医药卫生—肿瘤]