Research progress in Shigella in the postgenomic era  

作　　者：PENG JunPing, YANG Jian & JIN Qi State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology,Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100176, China 

出　　处：《Science China(Life Sciences)》2010年第11期1284-1290,共7页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China (Grant No. 30700033);National Basic Research Program of China (Grant Nos. 2009CB522603 and 2005CB522904)

摘　　要：Gram-negative,facultative intracellular anaerobes of the genus Shigella,the principal etiologic agents of shigellosis,continue to pose a threat to public health. Shigellosis causes 1.1 million deaths with over 164 million annual cases. The Shigella spp. can be divided into four serogroups:Shigella dysenteriae,Shigella flexneri, Shigella boydii and Shigella sonnei. The completion of seven Shigella genome sequences of representative strains from each of the Shigella species has introduced an era of whole-genome study.This paper reviews contemporary understanding of genomics,transcriptomics,proteomics and the structural biology of Shigella.Gram-negative,facultative intracellular anaerobes of the genus Shigella,the principal etiologic agents of shigellosis,continue to pose a threat to public health. Shigellosis causes 1.1 million deaths with over 164 million annual cases. The Shigella spp. can be divided into four serogroups:Shigella dysenteriae,Shigella flexneri, Shigella boydii and Shigella sonnei. The completion of seven Shigella genome sequences of representative strains from each of the Shigella species has introduced an era of whole-genome study.This paper reviews contemporary understanding of genomics,transcriptomics,proteomics and the structural biology of Shigella.

关 键 词：SHIGELLA GENOMICS TRANSCRIPTOMICS PROTEOMICS structural BIOLOGY 

分 类 号：R378[医药卫生—病原生物学]