Construction of tissue-engineered cartilage using human placenta-derived stem cells  

作　　者：LIU DaShun1,2,HUI HuangFu3,CHAI XiangBin3,WANG BinQuan3 & QIU JianHua1 1 Department of ENT,Xijing Hospital,the Foruth Military Medical University of PLA,Xi’an 710032,China 2 Department of ENT,264 Hospital of PLA,Taiyuan 030001,China 3 Department of ENT,the First Hospital of Shanxi Medical University,Taiyuan 030001,China 

出　　处：《Science China(Life Sciences)》2010年第2期207-214,共8页中国科学（生命科学英文版）

摘　　要：Human placenta-derived stem cells (hPDSCs) were isolated by trypsinization and further induced into cartilage cells in vitro.The engineered cartilage was constructed by combining hPDSCs with collagen sponge and the cartilage formation was observed by implantation into nude mice.Results showed that hPDSCs featured mesenchymal stem cells and maintained proliferation in vitro for over 30 passages while remaining undifferentiated.All results indicated that hPDSCs have the potential to differentiate into functional cartilage cells in vitro when combined with collagen sponge,which provided experimental evidence for prospective clinical application.Human placenta-derived stem cells (hPDSCs) were isolated by trypsinization and further induced into cartilage cells in vitro.The engineered cartilage was constructed by combining hPDSCs with collagen sponge and the cartilage formation was observed by implantation into nude mice.Results showed that hPDSCs featured mesenchymal stem cells and maintained proliferation in vitro for over 30 passages while remaining undifferentiated.All results indicated that hPDSCs have the potential to differentiate into functional cartilage cells in vitro when combined with collagen sponge,which provided experimental evidence for prospective clinical application.

关 键 词：human placenta-derived stem cells COLLAGEN SPONGE CARTILAGE tissue engineering 

分 类 号：R318.0[医药卫生—生物医学工程]