Preparation of giant unilamellar CdTe quantum dot vesicles and their metabolic pathway in vivo  

作　　者：WANG XianXiang1,3,YANG ZhongKe2,SAN Zhi1,PEN Xi2 & HUANG QianMing1 1College of Biology and Science,Sichuan Agricultural University,Ya’an 625014,China 2College of Veterinary Medicine,Sichuan Agricultural University,Ya’an 625014,China 3College of Chemistry,Sichuan University,Chengdu 610041,China 

出　　处：《Science China Chemistry》2010年第8期1718-1722,共5页中国科学（化学英文版）

基　　金：support from the Science Foundation of Sichuan Agricultural University for Distinguished Young Teachers (007202)

摘　　要：Glutathione (GSH) capped CdTe quantum dots (QDs) with photoluminescence quantum yields of 61% and the maximum emitting at 601.2 nm were prepared in water phase.Giant unilamellar CdTe quantum dot vesicles (GUVs-CdTe),with diameters larger than 1.5 μm,were obtained using lower-pressure evaporation techniques with soybean lecithin.Compared with other QD liposomes,the entrapment efficiency of GUVs-CdTe for QDs has been significantly improved to 86.3%.After GUVs-CdTe were injected into mice through the tail vein,the fluorescence microscopy of tissue sections showed that GUVs-CdTe could not pass through the blood-brain barrier and air-blood barrier,which were removed mostly by the reticuloendothelial system and were widely distributed in the spleen and the liver.This behavior is the same as the character of the metabolic pathway of giant unilamellar vesicles by intravenous injections in mice.Glutathione (GSH) capped CdTe quantum dots (QDs) with photoluminescence quantum yields of 61% and the maximum emitting at 601.2 nm were prepared in water phase.Giant unilamellar CdTe quantum dot vesicles (GUVs-CdTe),with diameters larger than 1.5 μm,were obtained using lower-pressure evaporation techniques with soybean lecithin.Compared with other QD liposomes,the entrapment efficiency of GUVs-CdTe for QDs has been significantly improved to 86.3%.After GUVs-CdTe were injected into mice through the tail vein,the fluorescence microscopy of tissue sections showed that GUVs-CdTe could not pass through the blood-brain barrier and air-blood barrier,which were removed mostly by the reticuloendothelial system and were widely distributed in the spleen and the liver.This behavior is the same as the character of the metabolic pathway of giant unilamellar vesicles by intravenous injections in mice.

关 键 词：QUANTUM DOTS GIANT unilamellar QUANTUM DOT vesicles METABOLIC pathway 

分 类 号：O614.242[理学—无机化学]