Pathophysiology and treatment of Barrett's esophagus  

作　　者：Daniel S Oh Steven R DeMeester 

机构地区：[1]Department of Surgery,The University of Southern California,Keck School of Medicine,Los Angeles,CA 90033,United States

出　　处：《World Journal of Gastroenterology》2010年第30期3762-3772,共11页世界胃肠病学杂志（英文版）

摘　　要：Gastroesophageal reflux disease (GERD) affects an estimated 20% of the population in the United States. About 10%-15% of patients with GERD develop Barrett’s esophagus, which can progress to adenocarcinoma, currently the most prevalent type of esophageal cancer. The esophagus is normally lined by squamous mucosa, therefore, it is clear that for adenocarcinoma to develop, there must be a sequence of events that result in transformation of the normal squamous mucosa into columnar epithelium. This sequence begins with gastroesophageal reflux, and with continued injury metaplastic columnar epithelium develops. This article reviews the pathophysiology of Barrett’s esophagus and implications for its treatment. The effect of medical and surgical therapy of Barrett’s esophagus is compared.Gastroesophageal reflux disease (GERD) affects an estimated 20% of the population in the United States. About 10%-15% of patients with GERD develop Barrett’s esophagus, which can progress to adenocarcinoma, currently the most prevalent type of esophageal cancer. The esophagus is normally lined by squamous mucosa, therefore, it is clear that for adenocarcinoma to develop, there must be a sequence of events that result in transformation of the normal squamous mucosa into columnar epithelium. This sequence begins with gastroesophageal reflux, and with continued injury metaplastic columnar epithelium develops. This article reviews the pathophysiology of Barrett’s esophagus and implications for its treatment. The effect of medical and surgical therapy of Barrett’s esophagus is compared.

关 键 词：GASTROESOPHAGEAL REFLUX disease Barrett’s ESOPHAGUS Lower ESOPHAGEAL SPHINCTER ESOPHAGEAL motility Proton pump inhibitors ANTIREFLUX surgery 

分 类 号：R571[医药卫生—消化系统] R735.1[医药卫生—内科学]