Design,synthesis and antitumor activity of 6,7-disubstituted-4-(heteroarylamino)quinoline-3-carbonitrile derivatives  

作　　者：Bao Liu,Qi Dong You,Zhi Yu Li Department of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China 

出　　处：《Chinese Chemical Letters》2010年第5期554-557,共4页中国化学快报（英文版）

基　　金：supported by National Natural Science Foundation of China(No.30371676)

摘　　要：A series of new 6,7-disubstituted-4-(benzothiazol-6-ylamino)quinoline-3-carbonitrile derivatives(12a-l) were synthesized.The cytotoxicity of 12 new compounds was evaluated in AGS,HepG2 and HT-29 cell lines.The results showed that compounds 12g, 12h,12i,12k and 12l displayed more potent cytotoxic activities than Bosutinib,compound 12l exhibited the most potent antitumor activity among the tested compounds.A series of new 6,7-disubstituted-4-(benzothiazol-6-ylamino)quinoline-3-carbonitrile derivatives(12a-l) were synthesized.The cytotoxicity of 12 new compounds was evaluated in AGS,HepG2 and HT-29 cell lines.The results showed that compounds 12g, 12h,12i,12k and 12l displayed more potent cytotoxic activities than Bosutinib,compound 12l exhibited the most potent antitumor activity among the tested compounds.

关 键 词：3-Quinolinecarbonitrile derivatives SYNTHESIS ANTITUMOR 

分 类 号：O626.2[理学—有机化学]