Nickel-catalyzed enantioselective hydrovinylation of silyl-protected allylic alcohols:An efficient access to homoallylic alcohols with a chiral quaternary center  

作　　者：ZHANG Qi,ZHU Shou-Fei,CAI Yan,WANG Li-Xin & ZHOU Qi-Lin State Key Laboratory and Institute of Elemento-organic Chemistry,Nankai University,Tianjin 300071,China 

出　　处：《Science China Chemistry》2010年第9期1899-1906,共8页中国科学（化学英文版）

基　　金：the National Natural Science Foundation of China;the National Basic Research Program of China (973 Program) (2006CB806106, 2010CB833300);the Ministry of Health (2009ZX09501-017);"111" Project of the Ministry of Education of China (B06005) for financial support

摘　　要：Asymmetric hydrovinylation of silyl-protected allylic alcohols catalyzed by nickel complexes of chiral spiro phosphoramidite ligands was developed.A series of homoallylic alcohols with a chiral quaternary center were produced in high yields(up to 97%) and high enantioselectivities(up to 95% ee).The reaction provides an efficient method for preparing bifunctional compounds with a chiral quaternary carbon center.Asymmetric hydrovinylation of silyl-protected allylic alcohols catalyzed by nickel complexes of chiral spiro phosphoramidite ligands was developed.A series of homoallylic alcohols with a chiral quaternary center were produced in high yields(up to 97%) and high enantioselectivities(up to 95% ee).The reaction provides an efficient method for preparing bifunctional compounds with a chiral quaternary carbon center.

关 键 词：asymmetric hydrovinylation CHIRAL SPIRO phosphorus ligands functionalized olefins CHIRAL QUATERNARY CENTER 

分 类 号：O643.32[理学—物理化学]