Hypocrellin B doped and pH-responsive silica nanoparticles for photodynamic therapy  

作　　者：LI ZhaoBo1,2,WANG JianGuang1,2,CHEN JingRong1,LEI WanHua1,WANG XueSong1 & ZHANG BaoWen1 1Key Laboratory of Photochemical Conversion and Optoelectronic Materials,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100190,China 2Graduate University of Chinese Academy of Sciences,Beijing 100049,China 

出　　处：《Science China Chemistry》2010年第9期1994-1999,共6页中国科学（化学英文版）

基　　金：the financial support from the National Natural Science Foundation of China (20772133, 20873170);Chinese Academy of Sciences (KJCX2YWH08)

摘　　要：pH-responsive 1O2 photosensitizing systems may serve as selective photodynamic therapy(PDT) agents by targeting the acidic interstitial fluid of many kinds of tumors.In this work,a natural and clinically used photosensitizer(Hypocrellin B,HB) and a pH indicator(Bromocresol Purple,BCP) were co-encapsulated in organically modified silica nanoparticles.BCP successfully regulated the 1O2 generation efficiency of HB through the "inner filter" effect,which shows much stronger 1O2 generation ability in an acidic than in a basic environment.In vitro experiments also demonstrated that HB-doped nanoparticles are effective in killing tumor cells by PDT.pH-responsive 1O2 photosensitizing systems may serve as selective photodynamic therapy(PDT) agents by targeting the acidic interstitial fluid of many kinds of tumors.In this work,a natural and clinically used photosensitizer(Hypocrellin B,HB) and a pH indicator(Bromocresol Purple,BCP) were co-encapsulated in organically modified silica nanoparticles.BCP successfully regulated the 1O2 generation efficiency of HB through the "inner filter" effect,which shows much stronger 1O2 generation ability in an acidic than in a basic environment.In vitro experiments also demonstrated that HB-doped nanoparticles are effective in killing tumor cells by PDT.

关 键 词：photodynamic THERAPY pH RESPONSIVE bromocresol PURPLE HYPOCRELLIN b SILICA nanoparticles 

分 类 号：O613.72[理学—无机化学]