the National Natural Science Foundation of China(No.82073955 and 81773696);the Priority Academic Program Development of the Jiangsu Higher Education Institutes(PAPD).
Hypocrellins are major bioactive perylenequinones from Shiraia fruiting bodies and have been developed as efficient photosensitizers for photodynamic therapy.Pseudomonas is the second dominant genus inside Shiraia fru...
Project supported by the National Natural Science Foundation of China(81473183,81773696);the Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(KYCX17_2042)
Rare earth elements(REEs)have been widely applied as efficient elicitors to improve production of biologically important secondary metabolites in plants.However,their effects on microbial secondary metabolites were se...
Supported by Shandong Provincial Natural Science Foundation(ZR2016BL16&ZR2016CL01);Doctor Foundation of Binzhou University(2016Y17&2016Y02);Project of Shandong Province Higher Educational Science and Technology Program(J17KA120);Research Project of the University-level Teaching Reform of Binzhou University in 2017(BYJYYB201736);Schoolenterprise Co-construction Course Project of Binzhou University in 2017(BYXQGJ201706)
The fungus Shiraia bambusicola GZ19 M1 is biotechnologically important due to its ability to biosynthesis the pigment hypocrellins.Results showed that ethyl methane sulfonate( EMS) was effective mutagenic agent for st...
supported by the National Natural Science Foundation of China(Project No.81673214);The National Key Technology Research and National Key Technology Research and Development Program of the Ministry of Science and Technology of the People's Republic of China(Project No.2012BAD36B0502);the Priority Academic Program Development of Jiangsu Higher Educational Institutions(China)
Over recent decades, many studies have reported that hypocrellin A(HA) can eliminate cancer cells with proper irradiation in several cancer cell lines. However, the precise molecular mechanism underlying its anticance...
The project supported by the general grant fund from Hong Kong Research Grant Committee(476912);Health and Medical Research Fund(13120442);Innovation and Technology Fund of Shenzhen(CXZZ20120619150627260)
OBJECTIVE To prepare hypocrellin B-loaded apoferritin nanoparticles(HB-AFT NPs)for photodynamic therapy on tumor.METHODS HB-AFT NPs were prepared by taking advantage of the reversibleunfolding and refolding character ...
The project supported by Health and Medical Research Fund(13120442);the General Research Fund(GRF)Grant from Hong Kong Research Grant Committee(476912)
OBJECTIVE To investigate the killing effect of the combined treatment of ultrasound and hypocrellin B,an active component isolated from a natural product Hypocrella bambuase,on Candida albicans.METHODS At first,Candid...
The project supported by the General Research Fund Grant from Hong Kong Research Grant Committee(476912);Health and Medical Research Fund(13120442)
OBJECTIVE To investigate the effect of sonodynamic action on biofilm-producing Enterococcus faecalis using hypocrellin B from a natural product Hypocrella bambuase as a sensitizer.METHODS The uptake of hypocrellin B i...
The project supported by Health and Medical Research Fund(1100502,13120442and 12110442);the general research fund(GRF)grant from Hong Kong research grant committee(476912)
Malignant tumors and infectious diseases are two main threats to human beings.Photodynamic therapy(PDT)is an effective approach to treat malignancies and infections through the generation of reactive oxygen species(RO...
supported by the National Natural Science Foundation of China (Nos.21303223 and 311706144).
Photodynamic therapy(PDT)has been a routine treatment of tumors and some microvascular diseases,but clinically available photosensitizers are still scarce.Among all kinds of photo-sensitizers,hypocellins possess the m...