Drug-delivery and multifunction possibilities of hypocrellin photosensitizers  

作　　者：Hong Deng Jie Xie Jingquan Zhao 

机构地区：[1]Beijing National Laboratory for Molecular Sciences(BNLMS)Key Laboratory of Photochemistry,Institute of Chemistry Chinese Academy of Sciences P.O.Box 101,No.2,1st North Street Zhongguancun,Beijing 100190,P.R.China

出　　处：《Journal of Innovative Optical Health Sciences》2015年第1期27-39,共13页创新光学健康科学杂志（英文）

基　　金：supported by the National Natural Science Foundation of China (Nos.21303223 and 311706144).

摘　　要：Photodynamic therapy(PDT)has been a routine treatment of tumors and some microvascular diseases,but clinically available photosensitizers are still scarce.Among all kinds of photo-sensitizers,hypocellins possess the most characteristics of ideal photosensitizers,such as,high photo-activity but low dark toxicity,fast clearance from tssues.This review is focused on two main topics,drug-delivery problem of hypocrellins and how the environment-sensitive fluorescence of bypecrellins was used for recognition of various biomolecules.Drug-delivery of hypocrellins was mainly achieved in two strategies一preparing the drugdelivery vehicles and finding quantitatively amphiphilic derivatives.Hypocrellin fAuorescence originated from the intramolecular proton transfer is very distinct from other kinds of photosensitizers.Recently,it was proved that quan-titative hypocrellin ftuorescence could not only reoognize various biomolecules,including proteins,polysaocharides and lipids,but also distinguish the specific binding from nonspedifie binding with some kind of biomolecules.Meantime,hypocrellin fluorescence was pH sensitive.It is known that tumor cells or tses have the features of a large amount of lipid,neonatal collagen,over expression of polysaccharides,and lower pH values compared to normal tissues.According to the relative but not absolute specifcity,further studies on quantitative recognition of various biomolecules at a cellular level,may find a new clue to treat tumors by joint usage of photodynamic diagnosis(PDD)and PDT.

关 键 词：Hypocrellins photodynamie therapy drug delivery biomolecular recognition 

分 类 号：R73[医药卫生—肿瘤]