Organocatalytic enantioselective Michael addition reactions of fluoromalonates with α,β-unsaturated aldehydes  

作　　者：LI Hao1,JI YaFei2,LI Jian2,ZHANG ShiLei1,YU ChenGuang1 & WANG Wei1,2 1 Department of Chemistry and Chemical Biology,University of New Mexico,Albuquerque,NM 87131-0001,USA 2 Department of Pharmaceutical Sciences,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China 

出　　处：《Science China Chemistry》2010年第1期135-139,共5页中国科学（化学英文版）

基　　金：support for this work provided by the NSF (CHE-0704015)

摘　　要：A new organocatalytic enantioselective Michael addition of α-fluoromalonate to enals has been developed.The process is efficiently catalyzed by readily available chiral diphenylpyrolinol TES ether under mild reaction conditions to afford versatile highly enantioenriched fluorinated aldehydes.A new organocatalytic enantioselective Michael addition of α-fluoromalonate to enals has been developed.The process is efficiently catalyzed by readily available chiral diphenylpyrolinol TES ether under mild reaction conditions to afford versatile highly enantioenriched fluorinated aldehydes.

关 键 词：ORGANOCATALYSIS α β-unsaturated ALDEHYDES CHIRAL FLUORINATED compounds MICHAEL addition 

分 类 号：O643.32[理学—物理化学]