小泛素类蛋白对低氧诱导因子-1调控作用的研究进展  

Roles of SUMO in managing the stability of HIF-1

作　　者：郭传家[1] 李文军[2] 王蕾[1] 邹勇[1] 邹飞[2] 

机构地区：[1]南方医科大学第一临床医学院,广东广州510515 [2]南方医科大学公共卫生学院,广东广州510515

出　　处：《分子诊断与治疗杂志》2009年第4期279-282,共4页Journal of Molecular Diagnostics and Therapy

基　　金：国家重点基础研究发展计划(973计划)课题(NO.2006CB504100)

摘　　要：低氧诱导因子-1的表达和调节对肿瘤的发生、生长、血管形成、转移、凋亡、糖代谢及耐药性产生重要影响。小泛素类蛋白(small ubiquitin-related modifier,SUMO)是一类结构与泛素类似的小分子蛋白,在低氧应激等状态下表达增加,SUMO通过与泛素竞争HIF-1结合位点增强HIF-1的稳定性,包括SUMO化和去SUMO化及增强SENP活性和抑制pVHL作用等机制。这对寻找新的肿瘤干预靶点具有非常重要的意义。HIF-1 is a crucial regulating factor in hypoxia and its binding to the target genes can leads to systematic responses of cells to hypoxia,such as tumorigenesis,cell proliferation,energy metabolism,tumor angiogenesis,apoptosis and drug resistance.Recently,it was reported that SUMO expression was up-regulated in response to hypoxia and further enhanced the transcriptional activity of HIF-1α.To study SUMOylation of HIF-1 will help discover molecular mechanisms of tumor development.

关 键 词：低氧 小泛素类蛋白质 低氧诱导因子-1 肿瘤 泛素化 

分 类 号：R363[医药卫生—病理学]