联合检测血清F-PSA、T-PSA、F/T对前列腺癌的诊断意义  

The value of combined detetion of serum F-PSA ,T-PSA and F/T in the diagnosis of prostate carcinoma

作　　者：李国敏[1] 潘玉琴[2] 何帮顺[2] 张丽荣[2] 王波[2] 王书奎[2] 

机构地区：[1]姜堰市中医院检验科,江苏泰州225500 [2]南京医科大学附属南京第一医院中心实验室,江苏南京210006

出　　处：《现代生物医学进展》2009年第24期4684-4685,共2页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(30873022)

摘　　要：目的:探讨F-PSA、T-PSA及F-PSA/T-PSA(F/T)比值在前列腺癌诊断中的价值。方法:采用全自动免疫荧光分析仪检测50例正常健康体检者,78例前列腺癌患者(PCa)以及184例良性前列腺增生患者(BPH)血清中F-PSA、T-PSA及F/T比值,并对各组数值结果进行比较分析。结果:结果显示PCa组血清F-PSA、T-PSA高于BPH组及正常对照组(P<0.01,P<0.01);而F/T值低于BPH组及正常对照组(P<0.01,P<0.01)。T-PSA处于4-10ng/ml时,PCa组T-PSA水平与BPH组比较无显著性差异(P>0.05),但PCa组F/T值显著低于BPH组,两者间差异具有统计学意义(P<0.01)。结论:联合检测F-PSA、T-PSA及F/T比值对PCa的鉴别诊断及高危人群的筛查均具有重要意义。Objective: To investigate the value of F-PSA T-PSA and F/T in the diagnosis of prostate carcinoma. Methods: serum F-PSA and T-PSA were determined by CLIA in 78 prostate carcinoma patients with 184 benign prostatic hyperplasia patients and 50 healthy subjects, Ratio of F-PSA to T-PSA was calculated. Results:Serum F-PSA, T-PSA levels in patients with prostate carcinoma were significantly higher than that in benign prostatic hyperplasia and controls (P<0.01,P<0.01), but F/T was lower than that in benign prostatic hyperplasia and healthy subjects. The serum of T-PSA in prostate carcinoma patients had no relation with that in benign prostatic hyperplasia patients, but F/T was significantly lower than that in benign prostatic hyperplasia (p<0.01) Conclusion: combined detection of serum F-PSA ,T-PSA and F/T have significant value in differential diagnosis and screening of high-risk populations.

关 键 词：前列腺癌 良性前列腺增生 F-PSA T-PSA 

分 类 号：R737.25[医药卫生—肿瘤]