羊膜移植联合药物预防翼状胬肉复发的临床观察  

Combination of amniotic membrane grafts and medicine for preventing recurrence of pterygium:a clinical observation

作　　者：徐朝阳[1] 张俊华[1] 金威尔[1] 刘安[1] 陈文祥[1] 潘铭东[1] 

机构地区：[1]福建省人民医院眼科,福建福州350004

出　　处：《眼科新进展》2004年第3期207-208,共2页Recent Advances in Ophthalmology

基　　金：福建省教育厅科研基金资助 (编号 :JB0 10 0 5 0 )

摘　　要：目的　寻找高效低毒的防止翼状胬肉术后复发的药物。方法　对 134例 16 3眼原发性和复发性翼状胬肉患者施行翼状胬肉切除加羊膜移植术 ,联合应用糖皮质激素或丝裂霉素C、干扰素进行对照研究 ,以观察其复发率差异及术后并发症。结果　单纯应用糖皮质激素组复发率 17.6 5 % ,明显高于丝裂霉素C组 5 .4 5 %和干扰素组 5 .2 6 % ,有明显统计学差异 (P <0 .0 5 ) ,后 2组复发率无统计学差异 (P>0 0 5 )。丝裂霉素C组 1例并发后部巩膜炎 ,2例表层巩膜炎。干扰素组未发现全身及局部毒副作用。结论　干扰素是一种有效。Objective To search for an effective and less toxic medicine that can prevent the recurrence after pterygium excision.Methods One hundred and sixty three eyes of 134 patients of primary and recurrent pterygium who were all treated through pterygium excision and amnion transplantation were divided into three groups. They were respectively treated with glucocorticoids,mitomycin C or interferon. Then three groups were studied in order to observe the difference in the recurrence rate and complication after pterygium excision between them.Results The recurrence rate in the glucocorticoids group was 17.65%, which was significantly higher than that in mitomycin C group(5.45%)and the interferon group(5.26%)(P<0.05).There was no significant difference between the mitomycin C group and the interferon group (P>0.05). Later 1 case had posterior scleritis and 2 cases had episcleritis in the mitomycin C group.No side effect was found in the interferon group.Conclusion Interferon is an effective and safe medicine that can prevent the recurrence after pterygium excision.

关 键 词：翼状胬肉 羊膜移植 药物 复发 

分 类 号：R777.33[医药卫生—眼科]