Measurement and Prediction of Insertion Force for the Mosquito Fascicle Penetrating into Human Skin  

作　　者：X Q Kong C W Wu 

机构地区：[1]State Key Laboratory of Structural Analysis for Industrial Equipment,Department of Engineering Mechanics,Dalian University of Technology

出　　处：《Journal of Bionic Engineering》2009年第2期143-152,共10页仿生工程学报（英文版）

基　　金：supported by the National Natural Science Foundation of China (No.10672035,No.90816025,No.10721062);SRFDP (No.20060141007)

摘　　要：Mosquitoes are exceptional in their ability to pierce into human skin with a natural ultimate painless microneedle, named fascicle. Here the structure of the Aedes albopictus mosquito fascicle is obtained using a Scanning Electron Microscope (SEM), and the whole process of the fascicle inserting into human skin is observed using a high-speed video imaging technique. Direct measurements of the insertion force for mosquito fascicle to penetrate into human skin are reported. Results show that the mosquito uses a very low force (average 18 μN) to penetrate into the skin. This force is at least three orders of magnitude smaller than the reported lowest insertion force for an artificial microneedle with an ultra sharp tip to insert into the human skin. In order to understand the piercing mechanism of mosquito fascicle tip into human multilayer skin tissue, a numerical simulation is conducted to analyze the insertion process using a nonlinear finite element method. A good agreement occurs between the numerical results and the experimental measurements.Mosquitoes are exceptional in their ability to pierce into human skin with a natural ultimate painless microneedle, named fascicle. Here the structure of the Aedes albopictus mosquito fascicle is obtained using a Scanning Electron Microscope (SEM), and the whole process of the fascicle inserting into human skin is observed using a high-speed video imaging technique. Direct measurements of the insertion force for mosquito fascicle to penetrate into human skin are reported. Results show that the mosquito uses a very low force (average 18 μN) to penetrate into the skin. This force is at least three orders of magnitude smaller than the reported lowest insertion force for an artificial microneedle with an ultra sharp tip to insert into the human skin. In order to understand the piercing mechanism of mosquito fascicle tip into human multilayer skin tissue, a numerical simulation is conducted to analyze the insertion process using a nonlinear finite element method. A good agreement occurs between the numerical results and the experimental measurements.

关 键 词：BIOMIMETIC MICRONEEDLE MOSQUITO FASCICLE mechanics penetration 

分 类 号：Q66[生物学—生物物理学]