乳铁传递蛋白:功能卓越的乳生物活性蛋白(英文)  

Lactoferrin,a fascinating biological protein

作　　者：Jean -Paul Perraudin 

机构地区：[1]北京新百利恒康源国际贸易有限公司

出　　处：《中国食品添加剂》2009年第S1期285-293,共9页China Food Additives

摘　　要：乳铁蛋白是一种铁结合的糖蛋白,是具有多种生物功能的乳生物活性蛋白,具有非常重要的科学研究价值。在过去的二十年中,乳铁蛋白的各种生物功能已被深入研究和报道。从最初发现的抗微生物活性,到调节铁的吸收与代谢、免疫调节、促进细胞增长等其他功能,增强宿主的防御能力。乳铁蛋白可以作为预防和治疗人类多种疾病的药物在防止感染和抵抗病毒,抑制肿瘤发生与转移等方面发挥作用。本文概括了乳铁蛋白在抗菌、抗氧化,免疫调节,抗癌等方面的生物功能以及作用机理。Lactoferrin,an iron-binding glycoprotein with various significant biological functions,is the subject of a considerable number of scientific studies.Various biological functions of this protein have been reported during the past two decades.The antimicrobial activity of lactoferrin was reported initially and other properties of lactoferrin including regulation of iron transport,of the immune response and cellular functions were later elucidated.Many of its activities can be grouped under the heading of host defence.Respecting the quality of the molecule,lactoferrin offers real potential as a therapeutic agent,provide anti infection and anti-virus,tumorigenesis and metastasis.In this article,the current state of knowledge across the whole range of biological activities expressed by this fascinating protein were reviewed,including mechanism of anti-bacterial,anti-oxidant,immune regulator and anti-tumour activities.

关 键 词：乳铁蛋白 铁代谢 免疫功能 抗微生物 

分 类 号：R98[医药卫生—药品]