Aerodynamically Assisted Tip-Pen Direct Writing  

作　　者：刘丰 张人佶 

机构地区：[1]Advanced Manufacture Technology Center, China Academy of Machinery Science & Technology [2]State Key Laboratory of Advanced Forming Technology and Equipment [3]Department of Mechanical Engineering, Tsinghua University

出　　处：《Tsinghua Science and Technology》2009年第S1期116-119,共4页清华大学学报（自然科学版（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No. 50105008);the Specialized Research Fund for the Doctoral Program of Higher Education of MOE, P.R.C. (No. 20050003046)

摘　　要：Scaffolds require individual external shape and well-defined internal structure, which is of great importance for tissue engineering. Rapid prototyping (RP) uses layer-manufacturing strategies to create physical objects and has the advantage on scaffold fabrication. A new RP technology called aerodynamically assisted tip-pen direct writing was developed to construct the complex architectures. Compared with the traditional nozzle, the new nozzle has a micro-tip in the center of the micro-hole. The flow is determined by the gap between the micro-hole and micro-tip, which makes it practical for more accurate flow control. A highly accurate three-dimensional (3-D) micro-positioning system was employed with the new nozzle to deposit maltose structures. 3-D architectures had been made by this method, the width of fiber in which is about 120 μm. The results show that this method provides a possibility to construct 3-D scaffolds with tissue-scale features (i.e., 10-100 μm) without bad influence on the biological activities.Scaffolds require individual external shape and well-defined internal structure, which is of great importance for tissue engineering. Rapid prototyping (RP) uses layer-manufacturing strategies to create physical objects and has the advantage on scaffold fabrication. A new RP technology called aerodynamically assisted tip-pen direct writing was developed to construct the complex architectures. Compared with the traditional nozzle, the new nozzle has a micro-tip in the center of the micro-hole. The flow is determined by the gap between the micro-hole and micro-tip, which makes it practical for more accurate flow control. A highly accurate three-dimensional (3-D) micro-positioning system was employed with the new nozzle to deposit maltose structures. 3-D architectures had been made by this method, the width of fiber in which is about 120 μm. The results show that this method provides a possibility to construct 3-D scaffolds with tissue-scale features (i.e., 10-100 μm) without bad influence on the biological activities.

关 键 词：tip-pen direct writing micro fabrication rapid prototyping SCAFFOLD 

分 类 号：TP391.77[自动化与计算机技术—计算机应用技术]