免疫球蛋白重链基因重排与多发性骨髓瘤发病机制的研究进展  

Gene Rearrangement of Immunoglobulin Heavy Chain and the Pathogensis of Mutiple Myeloma

作　　者：程红[1] 杨凌[1] 何争春[1] 

机构地区：[1]昆明医学院第一附属医院血液科,云南昆明650032

出　　处：《昆明医科大学学报》2009年第S2期125-128,共4页Journal of Kunming Medical University

摘　　要：随着细胞遗传学和分子生物学技术的迅速发展,早期遗传学异常、骨髓微环境与骨髓瘤细胞的相互作用、粘附受体、抑癌基因的失活及肿瘤血管增生等多个方面都被证实可能参与多发性骨髓瘤(multiple myeloma,MM)的发病机制.但MM的发病机制目前仍尚未完全清楚.近年来免疫球蛋白(immunoglobulin,Ig)基因重排在该疾病的发生发展中的作用已经引起人们的重视.就对免疫球蛋白重链(IgH)基因重排与多发性骨髓瘤发病机制的关系作一综述.As the rapid development of the cell genetics and molecular biological technology,it has been confirmed that many factors may participate in the pathogenesis of multiple myeloma(MM),such as early genetic abnormality,the interaction between bone marrow micro-environment and bone marrow tumor cells,adhesion receptors,inactivation of tumor suppressor genes and tumor angiogenesis.But the pathogenesis of multiple myeloma(MM)has not yet been entirely clear at present.In recent years,the immune globulin(Immunoglobulin,Ig)gene rearrangement has been emphasized in this disease.In this article we reviewed the relationship between the immunoglobulin heavy chain(IgH)gene rearrangements and the pathogenesis of multiple myeloma.

关 键 词：免疫球蛋白重链 基因重排 多发性骨髓瘤 

分 类 号：R733.3[医药卫生—肿瘤]