整合素β_1、FN与CD_(34)在脑胶质瘤中的表达及与预后的关系  

Expression of integrin β_1,fibronectin and CD_(34) in glioma and their relationship with prognosis

作　　者：宋曙 万政强 陈海涛 

机构地区：[1]盐城市第一人民医院,江苏盐城224001

出　　处：《山东医药》2009年第52期17-19,共3页Shandong Medical Journal

摘　　要：目的检测整合素β1、纤维连接蛋白(FN)、血管生成因子CD34在脑胶质瘤中的表达,并探讨它们与胶质瘤患者术后生存率的关系。方法采用免疫组织化学SP法检测各组病例脑组织中整合素β1、FN和CD34的表达。结果整合素β1、FN在胶质瘤中表达的总阳性率分别为61.4%、54.3%,二者在不同级别胶质瘤中的表达差异有统计学意义(P均<0.05),并与胶质瘤病理分级呈正相关(P均<0.01);胶质瘤患者CD34标记的肿瘤内平均微血管密度(MVD)为34.7±6.3,其在不同级别胶质瘤中的表达有统计学差异(P<0.01),与胶质瘤病理分级呈正相关(P<0.01);胶质瘤中整合素β1蛋白、FN蛋白以及MVD值3者间两两呈正相关(P均<0.05);随着胶质瘤病理分级的升高及整合素β1、FN、MVD表达的增强,术后生存率下降(P均<0.05)。结论整合素β1、FN和MVD的高表达与胶质瘤的发生及恶性程度有关,联合检测有助于评估预后。Objective To investigate the expression of integrin β1,fibronectin(FN) and CD34 in glioma and to discuss their relationship with the prognosis of glioma patients.Method Immunohistochemistry method was used to detect integrin β1,FN and CD34 expression in glioma and normal brain tissues.Results The positive expression rate of integrin β1 and FN in glioma was 61.4%(43/70),54.3%(38/70) respectively.Integrin β1 and FN were positively correlated with pathological grading(r=0.347 5,P<0.01;r=0.406 7,P<0.01).Mean vessel density(MVD) in 70 gliomas was 34.7±6.3,which was positively correlated with the pathological grading(r=0.912 9,P<0.01).The expression of integrin β1,FN and MVD were positively correlated with each other(P<0.05).With the pathological grading up-regulating and the expression of integrin β1,FN,MVD increasing,the survival rate decreased(P<0.05).Conclusion Over-expression of integrin β1,FN and MVD might be correlated with genesis and the degree of malignancy of glioma.

关 键 词：神经胶质瘤 整合素Β1 纤维连接蛋白 CD34 预后 

分 类 号：R739.4[医药卫生—肿瘤]