幽门螺杆菌空泡毒素基因多态性研究进展  

PYLORUS SPIRAL BACILLUS VACUOLE TOXIN GENE POLYMORPHISM RESEARCH DEVELOPMENT

作　　者：王丽萍[1] 苏秉忠[2] 

机构地区：[1]内蒙古医学院,内蒙古呼和浩特010059 [2]内蒙古医学院附属医院消化内科

出　　处：《内蒙古医科大学学报》2008年第S2期99-102,共4页Journal of Inner Mongolia Medical University

摘　　要：幽门螺杆菌的感染与慢性胃炎、消化性溃疡,胃粘膜相关组织淋巴瘤及胃腺癌等疾病的发生密切相关。感染者发生疾病与幽门螺杆菌菌株的毒力、宿主遗传易感性,环境因素等有关,其中毒力是细菌致病的第一特征。空泡毒素是其重要的毒力因子之一。幽门螺杆菌致病性的差异,与毒素的基因多态性有关。而且幽门螺杆菌空泡毒素基因型在地域及民族分布上也存在差异。本文将近几年有关幽门螺杆菌空泡毒素的基因多态性、致病性、地域以及民族分布差异做一综述。Helicobacter pylori infection and chronic gastritis,peptic ulcers and gastric lymphoma and gastric cancer and other diseases closely related. The diseases related to infected with the virulence of Helicobacter pylori strains,the host genetic susceptibility and environmental factors related to the poisoning of pathogenic bacteria is the first characteristic.Its toxic vacuolation is an important virulence factor.Helicobacter pylori pathogenic differences related to the genetic polymorphism of the toxin.Helicobacter pylori vacuoles toxin genotype distribution in the geographical and ethnic differences also exist.Nearly years in this paper the Helicobacter pylori cavity of the toxin gene polymorphism.We do reviewe about the pathogenicity of different geographical and ethnic differences in the distribution do reviewed.

关 键 词：幽门螺杆菌 空泡毒素 基因多态性 差异 

分 类 号：R573[医药卫生—消化系统]