胃癌中雄激素受体和雌激素受体的表达及其临床意义  

THE EXPRESSION AND CLINICAL SIGNIFICANCE OF AR AND ER IN GASTRIC CANCER

作　　者：孙晓革[1] 闫晓红[2] 刘秀兰[2] 

机构地区：[1]内蒙古医学院附属医院放疗科,内蒙古呼和浩特010050 [2]内蒙古医学院细胞生物教研室

出　　处：《内蒙古医科大学学报》2008年第S1期522-525,共4页Journal of Inner Mongolia Medical University

摘　　要：目的:探讨胃癌组织中雄激素受体(AR)和雌激素受体(ER)的表达及临床意义。方法:1.采用化学发光免疫法测定胃癌病人血清中雌二醇(estradiol,E2),睾酮(testosterone,T)含量;2.用免疫组化SP法检测胃癌标本AR、ER蛋白的表达。结果:1.胃癌同性别组血清T、E2含量比对照组低,有极显著性差异(P<0.01)。2.胃癌组织AR阳性率为47.6%,ER阳性率为34%;癌旁组织中AR、ER阳性率分别为61.9%、66.7%,有显著性差异;AR、ER在胃癌中的阳性表达与肿瘤的组织类型、分化程度、淋巴结转移情况以及TNM分期有关。结论:AR、ER阳性表达的胃癌具有性激素依赖性,检测胃癌组织中的AR、ER对临床判定预后及进行内分泌治疗有一定的指导意义。Objective:To study the expression and the clinical significance of androgen receptors(AR) and estrogen receptor(ER) in gastric cancer tissue.Methods:1.Estradiol(E2) and testosterone(T) levels in serum of gastric cancer patients are determined by means of chemiluminescent immune.2.To detect the protein expression of AR and ER in gastric cancer by means of immunohistochemical SP method.Results:1.Serum levels of T and E2 in same gender were lower compared with the normal control and the distinction is obvious(P<0.01).2.The positive rate of AR is 47.6% and the positive rate of ER is 34%,the distinction in the comparison of positive rate of AR and ER in the side of cancer tissue is significant,they are 61.9% and 66.7%.The positive expression in gastric cancer is related to the tissue type of tumor,the grade of differentiation,the shift situation of lymph node and TNM stages.Conclusion:AR and ER positive gastric cancer has sex hormone dependency.The detection of AR and ER of gastric cancer is significant in deciding clinical prognosis and incretion treatment.

关 键 词：胃癌 AR ER 免疫组化 

分 类 号：R735.2[医药卫生—肿瘤]