Effect of Asparagus polysaccharide on the number and activity of erythrocyte complement receptor 1 (CD35) of S_(180) mice  

作　　者：JI Yu-bin,MIN Yong-cui,JI Chen-feng(Center of Research on Life Sciences and Environmental Sciences,Harbin University of Commerce,Harbin 150076,China Engineering Research Center of Natural Anticancer Drugs,Ministry of Education,Harbin 150076,China) 

出　　处：《沈阳药科大学学报》2008年第S1期69-69,共1页Journal of Shenyang Pharmaceutical University

摘　　要：Objective To study the effect of Asparagus officinalis polysaccharide on the number and activity of erythrocyte complement receptor 1 in S180 mice.Methods Red blood cells from mice venous blood were labeled by rat anti-mouse CD35 monoclonal antibody and FITC-conjugated goat anti-mouse antibody.Using flow cytometry,we determined the number of ECR1.Using microscope,we studied the adherence between erythrocyte immunity and C3b receptor or tumor-cell by RBC-C3bRR and DTER.Results Comparing the mean value of the number of CR1 on each RBC of high and middle groups with control groups,the mean value of the number of CR1,RBC-C3bRR and DTER of Asparagus officinalis polysaccharide groups are increased significantly.Conclusions Asparagus officinalis polysaccharide can improve the erythrocyte function of S180 mice,which may be one of its most important antitumor mechanisms.Objective To study the effect of Asparagus officinalis polysaccharide on the number and activity of erythrocyte complement receptor 1 in S180 mice.Methods Red blood cells from mice venous blood were labeled by rat anti-mouse CD35 monoclonal antibody and FITC-conjugated goat anti-mouse antibody.Using flow cytometry,we determined the number of ECR1.Using microscope,we studied the adherence between erythrocyte immunity and C3b receptor or tumor-cell by RBC-C3bRR and DTER.Results Comparing the mean value of the number of CR1 on each RBC of high and middle groups with control groups,the mean value of the number of CR1,RBC-C3bRR and DTER of Asparagus officinalis polysaccharide groups are increased significantly.Conclusions Asparagus officinalis polysaccharide can improve the erythrocyte function of S180 mice,which may be one of its most important antitumor mechanisms.

关 键 词：ASPARAGUS OFFICINALIS polysaccharide ERYTHROCYTE complement receptor type 1 the NUMBER of ECR1 RBC-C3B RR DTER 

分 类 号：R285[医药卫生—中药学]