Anti-osteoporosis effect of the standard extract of Pueraria Lobata  

作　　者：LI Ni1,XU Feng2,YU Yao-hong2,ZHOU Xue-ting2(1.Liaoning Food and Drug Administration Technical Evaluation centre,Shenyang 110023,China 2.Shenyang Pharmaceutical University,Shenyang 110016,China) 

出　　处：《沈阳药科大学学报》2008年第S1期124-124,共1页Journal of Shenyang Pharmaceutical University

摘　　要：Objective The standard extract of Pueraria Lobata(SEP)was extracted from the traditional Chinese medicine Pueraria Lobata.and the anti-osteoporotic effect of SEP were evaluated in the paper.Methods The ovariotomied rats were used simulating osteoporosis model,and characterized from thighbone measurement,bone density,blood biochemistry assay,emiction biochemistry,bone morphology and womb pathology were also determined.Results The ovariotomy causes rats' weight,serum ALP,Strap,bone calcium element,emiction calcium element,emiction hydroxide praline increased;bone calcium content,bone density and rigidity,thighbone wet weight,dry weight and ash weight remarkably reduced;and the bone anti-bend intensity,the maximum bend strength decreased,the bone girder thinner,or even be broken.This indicates that ovariotomy causes rats lost bone calcium and got osteoporosis.One month after operation,SEP was provided subsequently for 12 weeks to different samples(medicament quantity 2.5,1.25,0.625 g·kg-1;model group;fake operational group and masculine medicament estrogen group).It was found that SEP can suppress the weight increase caused by ovariotomy,improved the thighbone metrology standard of the OVX rats(the bone calcium content 26.2%,20.1% and 15.7% separately);increase the thighbone density and rigidity,the thighbone wet weight,dry weight and ash weight;increased blood calcium,blood phosphorus,decreasing ALP,Strap,increasing serum estradiol level,reducing bone calcium content;improve the emiction biochemistry characteristics:decreased emiction calcium,emiction hydroxide proline ejection amount;improved the OVX rats thighbone biomechanics characteristic:increased the anti-band intensity and maximum bend strength.Conclusions SEP exerted upon an inhibited effects on osteoporosis caused by ovariotomy.Objective The standard extract of Pueraria Lobata(SEP)was extracted from the traditional Chinese medicine Pueraria Lobata.and the anti-osteoporotic effect of SEP were evaluated in the paper.Methods The ovariotomied rats were used simulating osteoporosis model,and characterized from thighbone measurement,bone density,blood biochemistry assay,emiction biochemistry,bone morphology and womb pathology were also determined.Results The ovariotomy causes rats' weight,serum ALP,Strap,bone calcium element,emiction calcium element,emiction hydroxide praline increased;bone calcium content,bone density and rigidity,thighbone wet weight,dry weight and ash weight remarkably reduced;and the bone anti-bend intensity,the maximum bend strength decreased,the bone girder thinner,or even be broken.This indicates that ovariotomy causes rats lost bone calcium and got osteoporosis.One month after operation,SEP was provided subsequently for 12 weeks to different samples(medicament quantity 2.5,1.25,0.625 g·kg-1;model group;fake operational group and masculine medicament estrogen group).It was found that SEP can suppress the weight increase caused by ovariotomy,improved the thighbone metrology standard of the OVX rats(the bone calcium content 26.2%,20.1% and 15.7% separately);increase the thighbone density and rigidity,the thighbone wet weight,dry weight and ash weight;increased blood calcium,blood phosphorus,decreasing ALP,Strap,increasing serum estradiol level,reducing bone calcium content;improve the emiction biochemistry characteristics:decreased emiction calcium,emiction hydroxide proline ejection amount;improved the OVX rats thighbone biomechanics characteristic:increased the anti-band intensity and maximum bend strength.Conclusions SEP exerted upon an inhibited effects on osteoporosis caused by ovariotomy.

关 键 词：SEP ovariotomy OSTEOPOROSIS 

分 类 号：R285[医药卫生—中药学]