急性胰腺炎患者血清肿瘤坏死因子α与肝细胞生长因子水平及临床意义的研究  

Changes and clinical meaning of tumor necrosis factor-α and hepatocyte growth factor in acute pancreatitis

作　　者：贺中黎 余志彬[1] 

机构地区：[1]天府矿务局三汇医院,重庆400704

出　　处：《中国医药指南》2008年第24期64-65,共2页Guide of China Medicine

摘　　要：目的探讨急性胰腺炎(AP)患者血清肿瘤坏死因子α(TNF-α)、肝细胞生长因子(HGF)的水平变化,以分析其变化规律及对病情判断的价值。方法应用ELISA测定39例急性胰腺炎(AP)及20例对照组血清TNF-α和HGF水平。结果AP患者血清TNFα和HGF水平明显高于对照组(P<0.01),在发病第1天,重症AP患者TNF-α水平明显高于轻症AP患者,而HGF则轻症AP患者较高,差异有统计学意义(P<0.01)。结论TNF-α和HGF参与了急性胰腺炎的发生发展过程,可作为AP早期诊断的参考指标。Objective To assess the changes of serum levels of tumor necrosis factor-α(TNF-α)and hepatocyte growth factor (HGF)in 39 patients with acute pancreatitis(AP),finding the rules of changes and their value.Methods The serum levels of TNF-α,HGF in 39 AP patients and 20 normal subjects were tested by ELISA.Results The level of serum TNF-αand HGF in AP patients were significantly higher than that in healthy people(P<0.01).In the 1st day after than that in the mild acute pancreatitis, however the serum levels of HGF in the mild acute pancratitis were higher,the difference was significant(P<0.01).Conclusion The serum levers of TNF-αand HGF are related to the development of acute pancereatitis.It can be the reference indicator of the early diagnose of acute pancreatitis.

关 键 词：急性胰腺炎 肿瘤坏死因子Α 肝细胞生长因子 

分 类 号：R576[医药卫生—消化系统]