Molecular phylogeny of coronaviruses including human SARS-CoV  

作　　者：GAO Lei QI Ji WEI Haibin SUN Yigang HAO Bailin 

机构地区：[1]Institute of Theoretical Physics,Chinese Academy of Sciences,Bei-jing 100080,China [2]T-Life Research Center,Fudan University,Shanghai 200433,China [3]Graduate School,Zhejiang University,Hangzhou 310027,China [4]Hangzhou Branch,Beijing Genomics Institute,Chinese Academy of Sciences,Hangzhou 310008,China

出　　处：《Chinese Science Bulletin》2003年第12期1170-1174,共3页

摘　　要：Phylogenetic tree of coronaviruses (CoVs) in-cluding the human SARS-associated virus is reconstructed from complete genomes by using our newly developed K- string composition approach. The relation of the human SARS-CoV to other coronaviruses, i.e. the rooting of the tree is suggested by choosing an appropriate outgroup. SARS-CoV makes a separate group closer but still distant from G2 (CoVs in mammalian host). The relation between different isolates of the human SARS virus is inferred by first constructing an ultrametric distance matrix from counting sequence variations in the genomes. The resulting tree is consistent with clinic relations between the SARS-CoV isolates. In addition to a larger variety of coronavirus ge-nomes these results provide phylogenetic knowledge based on independent novel methodology as compared to recent phylogenetic studies on SARS-CoV.Phylogenetic tree of coronaviruses (CoVs) including the human SARS-associated virus is reconstructed from complete genomes by using our newly developed K-string composition approach. The relation of the human SARS-CoV to other coronaviruses, i.e. the rooting of the tree is suggested by choosing an appropriate outgroup. SARS-CoV makes a separate group closer but still distant from G2 (CoVs in mammalian host). The relation between different isolates of the human SARS virus is inferred by first constructing an ultrametric distance matrix from counting sequence variations in the genomes. The resulting tree is consistent with clinic relations between the SARS-CoV isolates. In addition to a larger variety of coronavirus genomes these results provide phylogenetic knowledge based on independent novel methodology as compared to recent phylogenetic studies on SARS-CoV.

关 键 词：SEVERE acute RESPIRATORY SYNDROME (SARS) CORONAVIRUS molecular PHYLOGENY composition distance ultramericity. 

分 类 号：R373[医药卫生—病原生物学]