颅内脊索瘤64例临床分析  

Clinical Analysis of 64 Cases of Intracranial Chordomas

作　　者：曹晓运[1] 陈衔城[1] 毛颖 顾宇翔 

机构地区：[1]复旦大学附属华山医院神经外科,上海200040

出　　处：《中国神经肿瘤杂志》2003年第3期158-161,共4页Chinese Journal of Neuro-Oncology

摘　　要：背景与目的:颅内脊索瘤好发于颅底,侵袭范围广泛,手术全切除困难,是神经外科的难题之一。本文探讨颅内脊索瘤临床特点、诊断及手术入路的选择。方法:对自1992年1月～2002年8月间在本院手术治疗的64例颅内脊索瘤进行回顾性分析。结果:64例发病年龄为5～67岁,平均37.5岁。男女比例约为1.6:1。头痛、复视是本病最常见的症状。64例患者共接受69次手术,肿瘤全切21例,次全切除24例,部分切除19例。结论:目前颅内脊索瘤手术全切率仍低,预后差,宜行积极手术治疗,手术入路的选择需根据肿瘤的解剖位置和侵袭的方向而定。BACKGROUND & OBJECTIVE: Intracranial chordomas are aggressive tumor that typically developed in the skull base. It is a challenge for neurosurgeon to achieve complete removal. In this paper, we investigated the clinical characteristics, diagnosis and surgical approaches for intracranial chordomas. METHODS: The clinical data of 64 patients with intracranial chordomas, treated from Jan. 1992 to Aug. 2002 in our department, were reviewed. RESULTS: The patients' age at diagnosis ranged from 5 to 67 year—old (mean of 37. 5 years). The male to female ratio was 1. 6: 1. Headache and diplopia were the main clinical manifestations. Sixty-nine surgical procedures were performed in the 64 patients. Radical, subtotal, and partial resections were achieved in 21, 24, and 19 patients, respectively. CONCLUSIONS: Although the rate of achieving radical resection rate is still low, and the functional outcome is not always satisfactory, aggressive surgical resection remains the only treatment that a patient can have long term survival. The surgical approaches should be designed according to the location and the direction of tumour extension.

关 键 词：脑肿瘤 脊索瘤 外科手术 

分 类 号：R739.41[医药卫生—肿瘤]