脑梗死患者血清TNF-α和IL-8检测的临床意义  

The clinical significance of TNF-α and IL-8 in serum of patients with cerebral infarction

作　　者：辛夷[1] 肖伟忠[2] 张勇[3] 

机构地区：[1]兰州医学院手术学教研室,730000 [2]兰州医学院病理生理教研室,730000 [3]华中科技大学同济医学院附属协和医院神经内科

出　　处：《兰州医学院学报》2004年第2期25-26,49,共3页Journal of Lanzhou Medical College

摘　　要：目的　探讨急性脑梗死患者血清TNF -α和IL - 8变化的临床意义。方法　采用ELISA方法测定 62例脑梗死患者和 48例同龄健康体检者血清TNF -α和IL - 8含量 ,并分析它们与梗塞体积的关系。结果　急性脑梗死患者血清TNF -α和IL - 8明显高于对照组 ,它们与脑梗死体积存在明显相关性。结论　急性脑梗死患者TNF -α和IL - 8是明显升高的 。Objective To investigate the significance of serum levels(TNF-α、IL-8) in patients with cerebral infarction(CI). Methods The serum levels of TNF-α and IL-8 were measured in 62 patients with (CI)and 48 healthy subjects by ELISA. The volume of CI were determined in 62 patients with CI.Results The serum levels of TNF-α and IL-8 in patients with CI were significantly higher compared to those in control group. The positive correlation between the serum levels(TNF-α、IL-8) and the volume of CI had been shown.Conclusion The serum level of TNF-αand IL-8 were significantly elevated in the patients with CI,which suggested that TNF-α and IL-8 may play an important role in the pathogenesis of CI.

关 键 词：脑梗死 血清TNF-Α IL-8 肿瘤坏死因子 

分 类 号：R743.33[医药卫生—神经病学与精神病学]