Stacking interaction in metal complexes with compositions of DNA and heteroaromatic N-bases  

作　　者：Jl Liangnian & LE XueyiDepartment of Chemistry, Key Laboratory for the Gene Engineering of the Ministry of Education of China, and State Key Laboratory of Ultrafast Laser Spectroscopy, Zhongshan University, Guangzhou 510275, China Department of Applied C 

出　　处：《Chinese Science Bulletin》2002年第1期1-9,共9页

基　　金：Aknowledgements This work was supported by the collaboration project of China-Switzerland, the National Natural Science Foundation of China (Grant Nos. 30070188, 29871036 and 29731030).

摘　　要：The current development in the intramolecular aromatic-ring stacking interactions in the complexes with compositions of DNA and heteroaromatic N-bases has been reviewed to a great extent, especially the significant contributions in several important systems about ternary mixed-ligand complexes, including nucleotide-metal ion-po-lyaromatic amine, amino acid-metal ion-polyaromatic amine, nucleotide-metal ion-pyridine-like aromatic amine, nucleo-tide-metal ion-amino acid, nucleotide-metal ion-nucleic acid base, nucleic acid base-metal ion, and the important factors affecting the intramolecular aromatic-ring stacking interac-tions in the complexes. Based on the study of stacking inter-action in the complexes, the mechanism of interaction be-tween DNA molecules and complexes of heteroaromatic N-bases has been established, which is crucial for the design and synthesis of the complexes acting as molecular devices of DNA.The current development in the intramolecular aromatic-ring stacking interactions in the complexes with compositions of DNA and heteroaromatic N-bases has been reviewed to a great extent, especially the significant contributions in several important systems about ternary mixed-ligand complexes, including nucleotide-metal ion-polyaromatic amine, amino acid-metal ion-polyaromatic amine, nucleotide-metal ion-pyridine-like aromatic amine, nucleotide-metal ion-amino acid, nucleotide-metal ion-nucleic acid base, nucleic acid base-metal ion, and the important factors affecting the intramolecular aromatic-ring stacking interactions in the complexes. Based on the study of stacking interaction in the complexes, the mechanism of interaction between DNA molecules and complexes of heteroaromatic N-bases has been established, which is crucial for the design and synthesis of the complexes acting as molecular devices of DNA.

关 键 词：ternary MIXED-LIGAND complexes stacking interaction transition metal ion HETEROAROMATIC N-base NUCLEOTIDE amino acid. 

分 类 号：Q523[生物学—生物化学]