Synthesis of Optically Active β-Alkyl-α-methylene-γ-butyro- lactones from Enantioselective Biotransformation of Nitriles, an Unusual Inversion of Enantioselectivity  

作　　者：赵生敏 王梅祥 

出　　处：《Chinese Journal of Chemistry》2002年第11期1291-1299,1129,共10页中国化学（英文版）

基　　金：theMajorStateBasicResearchDevelopmentProgram (No.2 0 0 0 0 775 0 6 ) ,andtheNationalNaturalScienceFoundationofChina (No .2 0 0 0 32 0 2 0 )andChineseAcademyofSciences

摘　　要：A new approach to optically active β-alkyl-α-methylene-γ-butyrolactone derivatives was reported from the Rhodococcus sp. AJ270-catalyzed hydrolysis of appropriate nitriles. The inversion of enantioselectivity of the amidase has been observed when a methyl protection was introduced into the hydroxy group of the parent substrate.A new approach to optically active β-alkyl-α-methylene-γ-butyrolactone derivatives was reported from the Rhodococcus sp. AJ270-catalyzed hydrolysis of appropriate nitriles. The inversion of enantioselectivity of the amidase has been observed when a methyl protection was introduced into the hydroxy group of the parent substrate.

关 键 词：BIOTRANSFORMATION nitrile hydratase AMIDASE optically active β-alkyl-α-methylene-γ-butyrolactone inversion of enantioselectivity 

分 类 号：O623.624[理学—有机化学]