Penta-coordinate phosphorous compounds and biochemistry  

作　　者：林长学 韩波 赵玉芬 万荣 李艳梅 冯亚兵 成昌梅 

出　　处：《Science China Chemistry》2002年第4期337-348,共12页中国科学（化学英文版）

基　　金：This work was supported by the National Natural Science Foundation of China (Grant Nos. 20132020 and 20175026).

摘　　要：The relationship between penta-coordinate phosphorus compounds and biochemistry is briefly reviewed. Some interesting phenomena such as peptide formation, ester formation, ester exchange on phosphorus and N to O migration occur at room temperature when the amino group of amino acid is associated with phosphoryl group. Serine or threonine in conjugate of nucleo-side-amino acid could recognize different nucleobases. N-phosphoryl Histine and Ser-His dipep-tide could cleavage nucleic acid, protein and ester in neutral medium. It is found that the above phenomena all undergo penta-coordinate intermediate of phosphorus atom, which is proposed as the key factor to determine their activities.The relationship between penta-coordinate phosphorus compounds and biochemistry is briefly reviewed. Some interesting phenomena such as peptide formation, ester formation, ester exchange on phosphorus and N to O migration occur at room temperature when the amino group of amino acid is associated with phosphoryl group. Serine or threonine in conjugate of nucleo-side-amino acid could recognize different nucleobases. N-phosphoryl Histine and Ser-His dipeptide could cleavage nucleic acid, protein and ester in neutral medium. It is found that the above phenomena all undergo penta-coordinate intermediate of phosphorus atom, which is proposed as the key factor to determine their activities.

关 键 词：penta-coordinate phosphorus compounds BIOCHEMISTRY NUCLEOTIDE amino acid origin of life 

分 类 号：O623[理学—有机化学]